Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

Sandro Barni, Luca Livraghi, Maria Morritti, Patrizia Vici, Andrea Michelotti, Saverio Cinieri, Caterina Fontanella, Luca Porcu, Lucia Del Mastro, Fabio Puglisi

Research output: Contribution to journalArticle

Abstract

Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

Original languageEnglish
Pages (from-to)33-44
Number of pages12
JournalFuture Oncology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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eribulin
Breast Neoplasms
Safety
Therapeutics
Italy
Disease-Free Survival
Cohort Studies
Retrospective Studies
Databases
Survival

Keywords

  • database
  • eribulin mesylate
  • metastatic breast cancer
  • real-world
  • safety

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Eribulin in the treatment of advanced breast cancer : Real-world scenario from 39 Italian centers - ESEMPiO study. / Barni, Sandro; Livraghi, Luca; Morritti, Maria; Vici, Patrizia; Michelotti, Andrea; Cinieri, Saverio; Fontanella, Caterina; Porcu, Luca; Del Mastro, Lucia; Puglisi, Fabio.

In: Future Oncology, Vol. 15, No. 1, 01.01.2019, p. 33-44.

Research output: Contribution to journalArticle

Barni, Sandro ; Livraghi, Luca ; Morritti, Maria ; Vici, Patrizia ; Michelotti, Andrea ; Cinieri, Saverio ; Fontanella, Caterina ; Porcu, Luca ; Del Mastro, Lucia ; Puglisi, Fabio. / Eribulin in the treatment of advanced breast cancer : Real-world scenario from 39 Italian centers - ESEMPiO study. In: Future Oncology. 2019 ; Vol. 15, No. 1. pp. 33-44.
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