Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

Sandro Barni; Luca Livraghi; Maria Morritti; Patrizia Vici; Andrea Michelotti; Saverio Cinieri; Caterina Fontanella; Luca Porcu; Lucia Del Mastro; Fabio Puglisi

doi:10.2217/fon-2018-0324

Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

Sandro Barni, Luca Livraghi, Maria Morritti, Patrizia Vici, Andrea Michelotti, Saverio Cinieri, Caterina Fontanella, Luca Porcu, Lucia Del Mastro, Fabio Puglisi

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

Original language	English
Pages (from-to)	33-44
Number of pages	12
Journal	Future Oncology
Volume	15
Issue number	1
DOIs	https://doi.org/10.2217/fon-2018-0324
Publication status	Published - Jan 1 2019

Keywords

database
eribulin mesylate
metastatic breast cancer
real-world
safety

ASJC Scopus subject areas

Oncology
Cancer Research

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10.2217/fon-2018-0324

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title = "Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study",

abstract = "Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.",

keywords = "database, eribulin mesylate, metastatic breast cancer, real-world, safety",

author = "Sandro Barni and Luca Livraghi and Maria Morritti and Patrizia Vici and Andrea Michelotti and Saverio Cinieri and Caterina Fontanella and Luca Porcu and {Del Mastro}, Lucia and Fabio Puglisi",

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doi = "10.2217/fon-2018-0324",

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T1 - Eribulin in the treatment of advanced breast cancer

T2 - Real-world scenario from 39 Italian centers - ESEMPiO study

AU - Barni, Sandro

AU - Livraghi, Luca

AU - Morritti, Maria

AU - Vici, Patrizia

AU - Michelotti, Andrea

AU - Cinieri, Saverio

AU - Fontanella, Caterina

AU - Porcu, Luca

AU - Del Mastro, Lucia

AU - Puglisi, Fabio

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

AB - Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

KW - database

KW - eribulin mesylate

KW - metastatic breast cancer

KW - real-world

KW - safety

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Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

Abstract

Keywords

ASJC Scopus subject areas

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