Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

Sandro Barni; Luca Livraghi; Maria Morritti; Patrizia Vici; Andrea Michelotti; Saverio Cinieri; Caterina Fontanella; Luca Porcu; Lucia Del Mastro; Fabio Puglisi

doi:10.2217/fon-2018-0324

Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

Sandro Barni, Luca Livraghi, Maria Morritti, Patrizia Vici, Andrea Michelotti, Saverio Cinieri, Caterina Fontanella, Luca Porcu, Lucia Del Mastro, Fabio Puglisi

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

Original language	English
Pages (from-to)	33-44
Number of pages	12
Journal	Future Oncology
Volume	15
Issue number	1
DOIs	https://doi.org/10.2217/fon-2018-0324
Publication status	Published - Jan 1 2019

Keywords

database
eribulin mesylate
metastatic breast cancer
real-world
safety

ASJC Scopus subject areas

Oncology
Cancer Research

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10.2217/fon-2018-0324

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Eribulin in the treatment of advanced breast cancer : Real-world scenario from 39 Italian centers - ESEMPiO study. / Barni, Sandro; Livraghi, Luca; Morritti, Maria ; Vici, Patrizia; Michelotti, Andrea; Cinieri, Saverio; Fontanella, Caterina; Porcu, Luca; Del Mastro, Lucia ; Puglisi, Fabio.

In: Future Oncology, Vol. 15, No. 1, 01.01.2019, p. 33-44.

Research output: Contribution to journal › Article › peer-review

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AU - Livraghi, Luca

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AU - Vici, Patrizia

AU - Michelotti, Andrea

AU - Cinieri, Saverio

AU - Fontanella, Caterina

AU - Porcu, Luca

AU - Del Mastro, Lucia

AU - Puglisi, Fabio

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N2 - Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

AB - Aim: We performed a multicenter retrospective cohort study of eribulin mesylate (EM) use in Italy, to describe the current practice for metastatic breast cancer patients (ESEMPiO) in the real-world. Patients & methods: Baseline characteristics, treatment administration and safety were summarized using descriptive statistics. Results: No safety concerns were raised in the population enrolled in the ESEMPiO database and treated in a real-life practice. Median progression-free survival and overall survival were 3.2 and 10.1 months, respectively. EM activity was similar between breast cancer subtypes. Conclusion: In metastatic breast cancer patients treated with EM in 'real-world' setting, the clinician-registered outcomes were comparable to those reported in pivotal trials. Furthermore, EM maintained clinical activity and a tolerable safety profile.

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Eribulin in the treatment of advanced breast cancer: Real-world scenario from 39 Italian centers - ESEMPiO study

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Keywords

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