Abstract
Background: Metastatic breast cancer (MBC) is highly prevalent in middle-aged or elderly patients. Eribulin is a nontaxane microtubule inhibitor, approved for the treatment of pretreated MBC. This multicentric study (sponsored by GIOGer, Italian Group for Geriatric Oncology) was designed to assess the efficacy and tolerability of eribulin, according to parameters usually used in geriatric oncology. Subjects, Materials, and Methods: An observational study was conducted on 50 consecutive elderly patients with MBC. The primary endpoint was to evaluate the change in items score of comprehensive geriatric assessment (CGA) and health-related quality of life (HRQL). Italian versions of the CGA and HRQL questionnaires were administered at baseline, before the third and fifth cycles, and then every three cycles until treatment discontinuation. Secondary endpoints were efficacy and safety. Results: Overall, both EQ-5D scores and EQ-5D-3 L visual analogic scale did not significantly change from baseline; the percentage of subjects without problems doing usual activities tended to decrease during treatment (p for linear trend.018), and the percentage of patients with minor problems performing usual activities tended to increase (p for linear trend.012). Among CGA items, Instrumental Activities of Daily Living tended to decrease during treatment and Geriatric Depression Scale tended to increase. After 12 months follow-up, 24 patients (out of 47) showed clinical benefits; median progression-free survival was 4.49 months (2.10–10.33) and median OS was 7.31 months (3.70–14.03). The treatment was associated with mild toxicity. Conclusion: Eribulin treatment preserved quality of life and geriatric parameters included in the CGA, except for instrumental functioning and geriatric depression, in elderly patients with MBC. Implications for Practice: A collaboration between oncologist and geriatric specialists is essential in the management of patients with metastatic breast cancer, who are frequently elderly or frail. The assessment of geriatric parameters in the decision-making process can contribute to direct toward the most appropriate therapeutic plan and preserve the quality of life of patients. Eribulin does not seem to affect quality of life or worsen the overall geriatric status; therefore, it can be considered a suitable option for elderly patients with metastatic breast cancer.
| Original language | English |
|---|---|
| Journal | Oncologist |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2018 |
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Keywords
- Comprehensive geriatric assessment
- Elderly
- Eribulin mesylate
- Health-related quality of life
- Metastatic breast cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Eribulin Mesylate as Third or Subsequent Line Chemotherapy for Elderly Patients with Locally Recurrent or Metastatic Breast Cancer : A Multicentric Observational Study of GIOGer (Italian Group of Geriatric Oncology)-ERIBE. / Leo, Silvana; Arnoldi, Ermenegildo; Repetto, Lazzaro; Coccorullo, Zaira; Cinieri, Saverio; Fedele, Mina; Cazzaniga, Marina; Lorusso, Vito; Latorre, Agnese; Campanella, Giovanna; Ciccarese, Mariangela; Accettura, Caterina; Pisconti, Salvatore; Rinaldi, Antonio; Brunetti, Cosimo; Raffaele, Mimma; Coltelli, Luigi; Spazzapan, Salvatore; Fratino, Lucia; Petrucelli, Luciana; Biganzoli, Laura.
In: Oncologist, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eribulin Mesylate as Third or Subsequent Line Chemotherapy for Elderly Patients with Locally Recurrent or Metastatic Breast Cancer
T2 - A Multicentric Observational Study of GIOGer (Italian Group of Geriatric Oncology)-ERIBE
AU - Leo, Silvana
AU - Arnoldi, Ermenegildo
AU - Repetto, Lazzaro
AU - Coccorullo, Zaira
AU - Cinieri, Saverio
AU - Fedele, Mina
AU - Cazzaniga, Marina
AU - Lorusso, Vito
AU - Latorre, Agnese
AU - Campanella, Giovanna
AU - Ciccarese, Mariangela
AU - Accettura, Caterina
AU - Pisconti, Salvatore
AU - Rinaldi, Antonio
AU - Brunetti, Cosimo
AU - Raffaele, Mimma
AU - Coltelli, Luigi
AU - Spazzapan, Salvatore
AU - Fratino, Lucia
AU - Petrucelli, Luciana
AU - Biganzoli, Laura
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Metastatic breast cancer (MBC) is highly prevalent in middle-aged or elderly patients. Eribulin is a nontaxane microtubule inhibitor, approved for the treatment of pretreated MBC. This multicentric study (sponsored by GIOGer, Italian Group for Geriatric Oncology) was designed to assess the efficacy and tolerability of eribulin, according to parameters usually used in geriatric oncology. Subjects, Materials, and Methods: An observational study was conducted on 50 consecutive elderly patients with MBC. The primary endpoint was to evaluate the change in items score of comprehensive geriatric assessment (CGA) and health-related quality of life (HRQL). Italian versions of the CGA and HRQL questionnaires were administered at baseline, before the third and fifth cycles, and then every three cycles until treatment discontinuation. Secondary endpoints were efficacy and safety. Results: Overall, both EQ-5D scores and EQ-5D-3 L visual analogic scale did not significantly change from baseline; the percentage of subjects without problems doing usual activities tended to decrease during treatment (p for linear trend.018), and the percentage of patients with minor problems performing usual activities tended to increase (p for linear trend.012). Among CGA items, Instrumental Activities of Daily Living tended to decrease during treatment and Geriatric Depression Scale tended to increase. After 12 months follow-up, 24 patients (out of 47) showed clinical benefits; median progression-free survival was 4.49 months (2.10–10.33) and median OS was 7.31 months (3.70–14.03). The treatment was associated with mild toxicity. Conclusion: Eribulin treatment preserved quality of life and geriatric parameters included in the CGA, except for instrumental functioning and geriatric depression, in elderly patients with MBC. Implications for Practice: A collaboration between oncologist and geriatric specialists is essential in the management of patients with metastatic breast cancer, who are frequently elderly or frail. The assessment of geriatric parameters in the decision-making process can contribute to direct toward the most appropriate therapeutic plan and preserve the quality of life of patients. Eribulin does not seem to affect quality of life or worsen the overall geriatric status; therefore, it can be considered a suitable option for elderly patients with metastatic breast cancer.
AB - Background: Metastatic breast cancer (MBC) is highly prevalent in middle-aged or elderly patients. Eribulin is a nontaxane microtubule inhibitor, approved for the treatment of pretreated MBC. This multicentric study (sponsored by GIOGer, Italian Group for Geriatric Oncology) was designed to assess the efficacy and tolerability of eribulin, according to parameters usually used in geriatric oncology. Subjects, Materials, and Methods: An observational study was conducted on 50 consecutive elderly patients with MBC. The primary endpoint was to evaluate the change in items score of comprehensive geriatric assessment (CGA) and health-related quality of life (HRQL). Italian versions of the CGA and HRQL questionnaires were administered at baseline, before the third and fifth cycles, and then every three cycles until treatment discontinuation. Secondary endpoints were efficacy and safety. Results: Overall, both EQ-5D scores and EQ-5D-3 L visual analogic scale did not significantly change from baseline; the percentage of subjects without problems doing usual activities tended to decrease during treatment (p for linear trend.018), and the percentage of patients with minor problems performing usual activities tended to increase (p for linear trend.012). Among CGA items, Instrumental Activities of Daily Living tended to decrease during treatment and Geriatric Depression Scale tended to increase. After 12 months follow-up, 24 patients (out of 47) showed clinical benefits; median progression-free survival was 4.49 months (2.10–10.33) and median OS was 7.31 months (3.70–14.03). The treatment was associated with mild toxicity. Conclusion: Eribulin treatment preserved quality of life and geriatric parameters included in the CGA, except for instrumental functioning and geriatric depression, in elderly patients with MBC. Implications for Practice: A collaboration between oncologist and geriatric specialists is essential in the management of patients with metastatic breast cancer, who are frequently elderly or frail. The assessment of geriatric parameters in the decision-making process can contribute to direct toward the most appropriate therapeutic plan and preserve the quality of life of patients. Eribulin does not seem to affect quality of life or worsen the overall geriatric status; therefore, it can be considered a suitable option for elderly patients with metastatic breast cancer.
KW - Comprehensive geriatric assessment
KW - Elderly
KW - Eribulin mesylate
KW - Health-related quality of life
KW - Metastatic breast cancer
UR - http://www.scopus.com/inward/record.url?scp=85056411473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056411473&partnerID=8YFLogxK
U2 - 10.1634/theoncologist.2017-0676
DO - 10.1634/theoncologist.2017-0676
M3 - Article
JO - Oncologist
JF - Oncologist
SN - 1083-7159
ER -