Erionite and asbestos differently cause transformation of human mesothelial cells

P. Bertino, A. Marconi, L. Palumbo, B. M. Bruni, D. Barbone, S. Germano, A. U. Dogan, G. F. Tassi, C. Porta, L. Mutti, G. Gaudino

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperation between asbestos and other cofactors, such as SV40 virus infection. Nevertheless, several cases of MM were associated with environmental exposure to erionite in Turkey, where SV40 was never isolated in MM specimens. We show here that erionite is poorly cytotoxic, induces proliferating signals and high growth rate in human mesothelial cells (HMC). Long term exposure to erionite, but not to asbestos fibers, transforms HMC in vitro, regardless of the presence of SV40 sequences, leading to foci formation in cultured monolayers. Cells derived from foci display constitutive activation of Akt, NF-κB and Erk1/2, show prolonged survival and a deregulated cell cycle, involving cyclin D1 and E overexpression. Our results reveal that erionite is able per se to turn HMC into transformed highly proliferating cells and disclose the carcinogenic properties of erionite, prompting for a careful evaluation of environmental exposure to these fibers. The genetic predisposition to the effect of erionite is a separate subject for investigation.

Original languageEnglish
Pages (from-to)12-20
Number of pages9
JournalInternational Journal of Cancer
Volume121
Issue number1
DOIs
Publication statusPublished - Jul 1 2007

Fingerprint

Asbestos
Environmental Exposure
Zeolites
Cyclin E
Simian virus 40
Cyclin D1
Virus Diseases
Occupational Exposure
Genetic Predisposition to Disease
Turkey
erionite
Cell Cycle
Survival
Malignant Mesothelioma
Growth
Neoplasms

Keywords

  • Asbestos
  • Cell transformation
  • Erionite
  • Mesothelioma
  • Zeolite

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bertino, P., Marconi, A., Palumbo, L., Bruni, B. M., Barbone, D., Germano, S., ... Gaudino, G. (2007). Erionite and asbestos differently cause transformation of human mesothelial cells. International Journal of Cancer, 121(1), 12-20. https://doi.org/10.1002/ijc.22687

Erionite and asbestos differently cause transformation of human mesothelial cells. / Bertino, P.; Marconi, A.; Palumbo, L.; Bruni, B. M.; Barbone, D.; Germano, S.; Dogan, A. U.; Tassi, G. F.; Porta, C.; Mutti, L.; Gaudino, G.

In: International Journal of Cancer, Vol. 121, No. 1, 01.07.2007, p. 12-20.

Research output: Contribution to journalArticle

Bertino, P, Marconi, A, Palumbo, L, Bruni, BM, Barbone, D, Germano, S, Dogan, AU, Tassi, GF, Porta, C, Mutti, L & Gaudino, G 2007, 'Erionite and asbestos differently cause transformation of human mesothelial cells', International Journal of Cancer, vol. 121, no. 1, pp. 12-20. https://doi.org/10.1002/ijc.22687
Bertino P, Marconi A, Palumbo L, Bruni BM, Barbone D, Germano S et al. Erionite and asbestos differently cause transformation of human mesothelial cells. International Journal of Cancer. 2007 Jul 1;121(1):12-20. https://doi.org/10.1002/ijc.22687
Bertino, P. ; Marconi, A. ; Palumbo, L. ; Bruni, B. M. ; Barbone, D. ; Germano, S. ; Dogan, A. U. ; Tassi, G. F. ; Porta, C. ; Mutti, L. ; Gaudino, G. / Erionite and asbestos differently cause transformation of human mesothelial cells. In: International Journal of Cancer. 2007 ; Vol. 121, No. 1. pp. 12-20.
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