Erlotinib therapy in a patient with non-small-cell lung cancer and brain metastases

Giuseppe Altavilla, Carmela Arrigo, Maria Carmela Santarpia, Giuseppe Galletti, Giovanni Picone, Grazia Marabello, Chiara Tomasello, Vincenzo V. Pitini

Research output: Contribution to journalArticlepeer-review

Abstract

Brain metastases are a common occurrence and a major cause of mortality in non-small-cell lung cancer, with few systemic treatment options. Although targeting epidermal growth factor receptor-associated tyrosine kinase with erlotinib and gefitinib results in durable responses in some patients, the activity of these drugs against brain metastases has been poorly documented. In particular, few reports have so far reported the activity of erlotinib in this setting. Here we report the case of a male Italian smoker with an adeno-carcinoma of the lung whose lung cancer and brain metastases have both responded to erlotinib.

Original languageEnglish
Pages (from-to)31-33
Number of pages3
JournalJournal of Neuro-Oncology
Volume90
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • Brain metastases
  • Erlotinib
  • Lung cancer

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

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