The authors would like to inform the readers of a needed clarification in this article: The affiliation for Dr. Giovanni Fabbrini is as follows: Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed, Pozzilli (IS), Italy. The authors wish to apologise for any inconvenience caused. In the final version, complete legend and citation for figure 2 has not been included. It should be as follows: Figure 2: How activation of DCs by NM could trigger autoimmunity directed at dopaminergic neurons. Contact of DCs with NM triggers maturation of these cells that subsequently migrate from the brain into the cervical lymph nodes where they present NM to B- and T-lymphocytes. If NM-reactive lymphocytes are present, they get activated (primed) and secrete NM-specific antibodies (B cells) or exert NM-specific cytotoxic functions (T cells). Activation of microglia by NM would result in a proliferation of NM-specific T cells after contact with NM-presenting microglia. NM-specific antibodies and T cells may recognize NM-positive neurons and trigger their degradation. (From: J Neural Transm 2013;120:75-81).
ASJC Scopus subject areas
- Immunology and Allergy