Erythema induced by organic solvents: In vivo evaluation of oxygenized and deoxygenized haemoglobin by reflectance spectroscopy

E. Berardesca, P. H. Andersen, P. Bjerring, H. I. Maibach

Research output: Contribution to journalArticle


Objective: (i) using a new non-invasive technique capable of evaluating quantitatively and qualitatively the haemoglobin content of the skin (ii) to evaluate delipidization induced by organic solvents. Patients: 11 Caucasians treated for 1 min in a randomized manner on the volar forearm with a mixture of chloroform/methanol (2:1) (CM) and ether/acetone (1:1) (EA) to delipidize the skin. Method: erythema was evaluated by computerized remittance spectroscopy immediately after delipidization and hourly for 2 h. Results: only CM application induced subjectively observed and objectively quantified erythema. Erythema was related to a significant increase in oxygenized haemoglobin content due to dilatation of arterioles in the subpapillary plexus (P

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalContact Dermatitis
Issue number1
Publication statusPublished - 1992



  • Bioengineering methods
  • Chloroform/methanol
  • Erythema
  • Ether/acetone
  • Irritation
  • Organic solvents
  • Remittance spectroscopy

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

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