Erythrocyte antioxidant activity, serum ceruloplasmin, and trace element levels in subjects with alcoholic liver disease

G. Gerli, G. F. Locatelli, R. Mongiat, L. Zenoni, A. Agostoni, G. Moschini, D. Zafiropoulos, S. Bruno, S. Rossi, A. Vignati, G. Tarolo, M. Podda

Research output: Contribution to journalArticlepeer-review

Abstract

Erythrocyte antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) and reduced glutathione, serum ceruloplasmin, and serum trace elements (copper, zinc, iron, and selenium) related to antioxidant enzymes were assayed in subjects with alcoholic liver disease of different degrees of severity. The erythrocytes of subjects with moderate and severe alcoholic liver cirrhosis had an unbalanced antioxidant system (normal superoxide dismutase, low catalase and glutathione peroxidase activities, and low glutathione content). Serum ceruloplasmin levels were in the normal range. Levels of the serum trace elements zinc and selenium were significantly low in subjects with moderate and severe cirrhosis, whose red cell half-life was also significantly short, as measured by radioactive chromium. These data suggest that the erythrocytes of subjects with moderate and severe alcoholic liver cirrhosis are less protected against oxidant stress. The particular erythrocyte antioxidant system and serum trace element pattern may play a role in the genesis of hemolytic disorders and of alcoholic hepatic damage.

Original languageEnglish
Pages (from-to)614-618
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume97
Issue number5
Publication statusPublished - 1992

Keywords

  • Alcoholic liver disease
  • Catalase
  • Ceruloplasmin
  • Glutathione peroxidase
  • Reduced glutathione
  • Serum trace elements
  • Superoxide dismutase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Erythrocyte antioxidant activity, serum ceruloplasmin, and trace element levels in subjects with alcoholic liver disease'. Together they form a unique fingerprint.

Cite this