Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism

G. Vezzoli, M. C. Reina, D. Cusi, P. Casirati, L. Soldati, T. Azzani, R. Muirhead, G. Bianchi

Research output: Contribution to journalArticle

Abstract

The chronic effect of PTH on erythrocyte membrane Ca transport was examined. (Ca + Mg)ATPase activity and passive Sr influx were measured to assess the rate of passive Ca influx (total and inhibited by dihydropyridines [DHPs]), in erythrocytes from patients with primary hyperparathyroidism and normal controls. Erythrocyte Sr influx was lower in patients, due to a decreased DHP-sensitive Sr influx. Conversely, efflux activity of (Ca + Mg)ATPase was not different in patients and controls. We hypothesize that in primary hyperparathyroidism chronic PTH stimulation may induce a downregulation of the erythrocyte Ca influx mediated by DHP-sensitive Ca carrier.

Original languageEnglish
Pages (from-to)1505-1510
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume202
Issue number3
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Vezzoli, G., Reina, M. C., Cusi, D., Casirati, P., Soldati, L., Azzani, T., Muirhead, R., & Bianchi, G. (1994). Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism. Biochemical and Biophysical Research Communications, 202(3), 1505-1510. https://doi.org/10.1006/bbrc.1994.2101