Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism

G. Vezzoli, M. C. Reina, D. Cusi, P. Casirati, L. Soldati, T. Azzani, R. Muirhead, G. Bianchi

Research output: Contribution to journalArticle

Abstract

The chronic effect of PTH on erythrocyte membrane Ca transport was examined. (Ca + Mg)ATPase activity and passive Sr influx were measured to assess the rate of passive Ca influx (total and inhibited by dihydropyridines [DHPs]), in erythrocytes from patients with primary hyperparathyroidism and normal controls. Erythrocyte Sr influx was lower in patients, due to a decreased DHP-sensitive Sr influx. Conversely, efflux activity of (Ca + Mg)ATPase was not different in patients and controls. We hypothesize that in primary hyperparathyroidism chronic PTH stimulation may induce a downregulation of the erythrocyte Ca influx mediated by DHP-sensitive Ca carrier.

Original languageEnglish
Pages (from-to)1505-1510
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume202
Issue number3
DOIs
Publication statusPublished - 1994

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Dihydropyridines
Primary Hyperparathyroidism
Erythrocyte Membrane
Ca(2+) Mg(2+)-ATPase
Erythrocytes
Calcium
Membranes
Down-Regulation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism. / Vezzoli, G.; Reina, M. C.; Cusi, D.; Casirati, P.; Soldati, L.; Azzani, T.; Muirhead, R.; Bianchi, G.

In: Biochemical and Biophysical Research Communications, Vol. 202, No. 3, 1994, p. 1505-1510.

Research output: Contribution to journalArticle

Vezzoli, G, Reina, MC, Cusi, D, Casirati, P, Soldati, L, Azzani, T, Muirhead, R & Bianchi, G 1994, 'Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism', Biochemical and Biophysical Research Communications, vol. 202, no. 3, pp. 1505-1510. https://doi.org/10.1006/bbrc.1994.2101
Vezzoli, G. ; Reina, M. C. ; Cusi, D. ; Casirati, P. ; Soldati, L. ; Azzani, T. ; Muirhead, R. ; Bianchi, G. / Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism. In: Biochemical and Biophysical Research Communications. 1994 ; Vol. 202, No. 3. pp. 1505-1510.
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