Erythrocyte na+/li+ countertransport and glomerular hyperfiltration in insulin-dependent diabetics

Rossella Rota, José Timsit, Thierry Hannedouche, Aschour Ikeni, Christian Boitarc, Pascale Guicheney

Research output: Contribution to journalArticlepeer-review


Erythrocyte Na+/Li+ countertransport activity was investigated in 11 controls and 22 recent onset type I (insulin-dependent) diabetic patients with normal and high glomerular filtration rates. No differences in were observed in hyperfiltering compared to normofiltering patients or controls. The Na+/Li+ activity was correlated with blood glucose levels in insulin-dependent diabetics showing good glycemic control. Total cholesterol and triglyceride concentrations were similar among the three groups. In conclusion, enhanced Na+/Li+ countertransport activity is not associated, in our case, with diabetic condition per se and with early glomerular hyperfiltration and cannot be used as a marker of renal involvement in recent onset insulin-dependent diabetics. Am J Hypertens 1993;6:534-537.

Original languageEnglish
Pages (from-to)5345-5537
Number of pages193
JournalAmerican Journal of Hypertension
Issue number6
Publication statusPublished - 1993


  • Glomerular hyperfiltration
  • Na+/Li+ countertransport
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine


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