Erythrocyte na+/li+ countertransport and glomerular hyperfiltration in insulin-dependent diabetics

Rossella Rota, José Timsit, Thierry Hannedouche, Aschour Ikeni, Christian Boitarc, Pascale Guicheney

Research output: Contribution to journalArticle

Abstract

Erythrocyte Na+/Li+ countertransport activity was investigated in 11 controls and 22 recent onset type I (insulin-dependent) diabetic patients with normal and high glomerular filtration rates. No differences in were observed in hyperfiltering compared to normofiltering patients or controls. The Na+/Li+ activity was correlated with blood glucose levels in insulin-dependent diabetics showing good glycemic control. Total cholesterol and triglyceride concentrations were similar among the three groups. In conclusion, enhanced Na+/Li+ countertransport activity is not associated, in our case, with diabetic condition per se and with early glomerular hyperfiltration and cannot be used as a marker of renal involvement in recent onset insulin-dependent diabetics. Am J Hypertens 1993;6:534-537.

Original languageEnglish
Pages (from-to)5345-5537
Number of pages193
JournalAmerican Journal of Hypertension
Volume6
Issue number6
DOIs
Publication statusPublished - 1993

Fingerprint

Erythrocytes
Insulin
Glomerular Filtration Rate
Blood Glucose
Triglycerides
Cholesterol
Kidney

Keywords

  • Glomerular hyperfiltration
  • Na+/Li+ countertransport
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Erythrocyte na+/li+ countertransport and glomerular hyperfiltration in insulin-dependent diabetics. / Rota, Rossella; Timsit, José; Hannedouche, Thierry; Ikeni, Aschour; Boitarc, Christian; Guicheney, Pascale.

In: American Journal of Hypertension, Vol. 6, No. 6, 1993, p. 5345-5537.

Research output: Contribution to journalArticle

Rota, Rossella ; Timsit, José ; Hannedouche, Thierry ; Ikeni, Aschour ; Boitarc, Christian ; Guicheney, Pascale. / Erythrocyte na+/li+ countertransport and glomerular hyperfiltration in insulin-dependent diabetics. In: American Journal of Hypertension. 1993 ; Vol. 6, No. 6. pp. 5345-5537.
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