Erythrocyte polyamines and prognosis in colorectal cancer patients

Michele Linsalata, Silvana Leo, Vito Guerra, Alfredo Di Leo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Polyamines play a role in cell proliferation and in cancer development: they are mainly carried by red blood cells (RBCs). Abnormally high polyamine levels in RBCs have been demonstrated in patients with various types of cancer and the prognostic value of RBC polyamine levels has also been underlined. Our aims were to compare polyamine levels in RBCs from colorectal adenocarcinoma (CRA) patients with those from non neoplastic patients and to evaluate the prognostic value of pre-treatment polyamine erythrocyte levels. Patients and Methods: Sixty-one patients with colorectal cancer and 28 surgical patients affected by non neoplastic diseases were included in this study. RBCs polyamine levels were evaluated by HPLC. Results: significantly higher spermidine, spermine and total polyamine levels were found in RBCs from CRA patients compared to those from control patients. However, there was no significant difference in the survival of patients with different polyamine levels. Conclusion: Our findings show that RBC polyamine levels are not a biologic parameter that may help to discriminate between good and poor prognosis in colorectal cancer patients.

Original languageEnglish
Pages (from-to)2113-2117
Number of pages5
JournalAnticancer Research
Volume20
Issue number3 B
Publication statusPublished - 2000

Keywords

  • Colorectal adenocarcinoma
  • Erythrocytes
  • Polyamines
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint

Dive into the research topics of 'Erythrocyte polyamines and prognosis in colorectal cancer patients'. Together they form a unique fingerprint.

Cite this