Erythrocyte transmembrane Na and K fluxes in pseudohypoaldosteronism

Pietro Cugini, Gaetano Natoli, Gianfranco Gerlini, Loredana Di Palma, Rossella Rota, Mara D'Onofrio, Roberto Verna

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pseudohypoaldosteronism (PHA) is a disease characterized by hyponatremia, hypotension and dehydratation, despite the presence of hyperreninemic hyperaldosteronism. The membrane-bound Na,K ATPase activity and the transmembrane Na and K transport systems have been studied in vitro in red blood cells of two subjects, son and mother, affected by pseudohypoaldosteronism with different degrees of clinical involvement. Both parameters were significantly altered suggesting that the refractory response to mineralocorticoids is detectable, not only in kidneys and salivary and sweat glands, but also in red blood cells. Since pseudohypoaldosteronism, in its asymptomatic form, may be much more common than expected, we suggest the use of the tests described herein as a practical approach to the early diagnosis of pseudohypoaldosteronism in the investigation of sodium wasting syndromes.

Original languageEnglish
Pages (from-to)241-254
Number of pages14
JournalBiochemical Medicine and Metabolic Biology
Volume48
Issue number3
DOIs
Publication statusPublished - 1992

Fingerprint

Pseudohypoaldosteronism
Blood
Erythrocytes
Cells
Fluxes
Mineralocorticoids
Refractory materials
Adenosine Triphosphatases
Sodium
Wasting Syndrome
Membranes
Sweat Glands
Hyperaldosteronism
Hyponatremia
Salivary Glands
Hypotension
Early Diagnosis
Kidney

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Erythrocyte transmembrane Na and K fluxes in pseudohypoaldosteronism. / Cugini, Pietro; Natoli, Gaetano; Gerlini, Gianfranco; Di Palma, Loredana; Rota, Rossella; D'Onofrio, Mara; Verna, Roberto.

In: Biochemical Medicine and Metabolic Biology, Vol. 48, No. 3, 1992, p. 241-254.

Research output: Contribution to journalArticle

Cugini, P, Natoli, G, Gerlini, G, Di Palma, L, Rota, R, D'Onofrio, M & Verna, R 1992, 'Erythrocyte transmembrane Na and K fluxes in pseudohypoaldosteronism', Biochemical Medicine and Metabolic Biology, vol. 48, no. 3, pp. 241-254. https://doi.org/10.1016/0885-4505(92)90071-6
Cugini, Pietro ; Natoli, Gaetano ; Gerlini, Gianfranco ; Di Palma, Loredana ; Rota, Rossella ; D'Onofrio, Mara ; Verna, Roberto. / Erythrocyte transmembrane Na and K fluxes in pseudohypoaldosteronism. In: Biochemical Medicine and Metabolic Biology. 1992 ; Vol. 48, No. 3. pp. 241-254.
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AU - D'Onofrio, Mara

AU - Verna, Roberto

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