Erythrocyte transmembrane Na and K fluxes in pseudohypoaldosteronism

Pietro Cugini, Gaetano Natoli, Gianfranco Gerlini, Loredana Di Palma, Rossella Rota, Mara D'Onofrio, Roberto Verna

Research output: Contribution to journalArticlepeer-review


Pseudohypoaldosteronism (PHA) is a disease characterized by hyponatremia, hypotension and dehydratation, despite the presence of hyperreninemic hyperaldosteronism. The membrane-bound Na,K ATPase activity and the transmembrane Na and K transport systems have been studied in vitro in red blood cells of two subjects, son and mother, affected by pseudohypoaldosteronism with different degrees of clinical involvement. Both parameters were significantly altered suggesting that the refractory response to mineralocorticoids is detectable, not only in kidneys and salivary and sweat glands, but also in red blood cells. Since pseudohypoaldosteronism, in its asymptomatic form, may be much more common than expected, we suggest the use of the tests described herein as a practical approach to the early diagnosis of pseudohypoaldosteronism in the investigation of sodium wasting syndromes.

Original languageEnglish
Pages (from-to)241-254
Number of pages14
JournalBiochemical Medicine and Metabolic Biology
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism


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