Erythromycin estolate impairs the mitochondrial and microsomal calcium homeostasis: correlation with hepatotoxicity.

P. Richelmi; C. Baldi; L. Manzo; F. Berte; A. P. Martino; F. Mirabelli; G. Bellomo

Erythromycin estolate impairs the mitochondrial and microsomal calcium homeostasis: correlation with hepatotoxicity.

P. Richelmi, C. Baldi, L. Manzo, F. Berte, A. P. Martino, F. Mirabelli, G. Bellomo

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.

Original language	English
Pages (from-to)	298-302
Number of pages	5
Journal	Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
Volume	7
Publication status	Published - 1984

ASJC Scopus subject areas

Medicine(all)

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Erythromycin estolate impairs the mitochondrial and microsomal calcium homeostasis : correlation with hepatotoxicity. / Richelmi, P.; Baldi, C.; Manzo, L.; Berte, F.; Martino, A. P.; Mirabelli, F.; Bellomo, G.

In: Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement, Vol. 7, 1984, p. 298-302.

Research output: Contribution to journal › Article › peer-review

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abstract = "The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.",

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AU - Martino, A. P.

AU - Mirabelli, F.

AU - Bellomo, G.

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AB - The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.

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