TY - JOUR
T1 - Erythromycin estolate impairs the mitochondrial and microsomal calcium homeostasis
T2 - correlation with hepatotoxicity.
AU - Richelmi, P.
AU - Baldi, C.
AU - Manzo, L.
AU - Berte, F.
AU - Martino, A. P.
AU - Mirabelli, F.
AU - Bellomo, G.
PY - 1984
Y1 - 1984
N2 - The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.
AB - The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.
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M3 - Article
C2 - 6595996
AN - SCOPUS:0021697867
VL - 7
SP - 298
EP - 302
JO - Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
JF - Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
SN - 0171-9750
ER -