Erythromycin estolate impairs the mitochondrial and microsomal calcium homeostasis: Correlation with hepatotoxicity

P. Richelmi, C. Baldi, L. Manzo

Research output: Contribution to journalArticle

Abstract

The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.

Original languageEnglish
Pages (from-to)298-302
Number of pages5
JournalArchives of Toxicology
Volume55
Issue numberSUPPL. 7
DOIs
Publication statusPublished - 1984

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Erythromycin Estolate
Homeostasis
Calcium
Erythromycin Ethylsuccinate
Macrolides
Cell death
Erythromycin
Surface-Active Agents
Sodium Dodecyl Sulfate
Rats
Hepatocytes
Cell Death
Anti-Bacterial Agents
Molecules

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Erythromycin estolate impairs the mitochondrial and microsomal calcium homeostasis : Correlation with hepatotoxicity. / Richelmi, P.; Baldi, C.; Manzo, L.

In: Archives of Toxicology, Vol. 55, No. SUPPL. 7, 1984, p. 298-302.

Research output: Contribution to journalArticle

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