Erythropoietin does not preserve motor neurons in a mouse model of familiai ALS

Giuliano Grignaschi; Eleonora Zennaro; Massimo Tortarolo; Novella Calvaresi; Caterina Bendotti

doi:10.1080/17482960600783456

Erythropoietin does not preserve motor neurons in a mouse model of familiai ALS

Giuliano Grignaschi, Eleonora Zennaro, Massimo Tortarolo, Novella Calvaresi, Caterina Bendotti

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the human Cu/Zn dependent-superoxide dismutase with G93A mutation (SOD1G93A), a model of familial amyotrophic lateral sclerosis. rHuEPO (4 unit/g BW s.c. three times/week), increased the haematocrit and induced a slight delay in impairment of motor function as measured by the rotating bar test. However, it did not prolong life span or reduce motor neuron loss in lumbar spinal cord. The effect on motor function may be due to the improvement of skeletal muscle oxygenation induced by chronic EPO administration.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Amyotrophic Lateral Sclerosis
Volume	8
Issue number	1
DOIs	https://doi.org/10.1080/17482960600783456
Publication status	Published - 2007

Keywords

Amyotrophic lateral sclerosis
Erythropoietin
Motor neuron
Transgenic SOD1G93A mice

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1080/17482960600783456

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title = "Erythropoietin does not preserve motor neurons in a mouse model of familiai ALS",

abstract = "Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the human Cu/Zn dependent-superoxide dismutase with G93A mutation (SOD1G93A), a model of familial amyotrophic lateral sclerosis. rHuEPO (4 unit/g BW s.c. three times/week), increased the haematocrit and induced a slight delay in impairment of motor function as measured by the rotating bar test. However, it did not prolong life span or reduce motor neuron loss in lumbar spinal cord. The effect on motor function may be due to the improvement of skeletal muscle oxygenation induced by chronic EPO administration.",

keywords = "Amyotrophic lateral sclerosis, Erythropoietin, Motor neuron, Transgenic SOD1G93A mice",

author = "Giuliano Grignaschi and Eleonora Zennaro and Massimo Tortarolo and Novella Calvaresi and Caterina Bendotti",

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AU - Calvaresi, Novella

AU - Bendotti, Caterina

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