Abstract
Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the human Cu/Zn dependent-superoxide dismutase with G93A mutation (SOD1G93A), a model of familial amyotrophic lateral sclerosis. rHuEPO (4 unit/g BW s.c. three times/week), increased the haematocrit and induced a slight delay in impairment of motor function as measured by the rotating bar test. However, it did not prolong life span or reduce motor neuron loss in lumbar spinal cord. The effect on motor function may be due to the improvement of skeletal muscle oxygenation induced by chronic EPO administration.
| Original language | English |
|---|---|
| Pages (from-to) | 31-35 |
| Number of pages | 5 |
| Journal | Amyotrophic Lateral Sclerosis |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 |
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Keywords
- Amyotrophic lateral sclerosis
- Erythropoietin
- Motor neuron
- Transgenic SOD1G93A mice
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Erythropoietin does not preserve motor neurons in a mouse model of familiai ALS. / Grignaschi, Giuliano; Zennaro, Eleonora; Tortarolo, Massimo; Calvaresi, Novella; Bendotti, Caterina.
In: Amyotrophic Lateral Sclerosis, Vol. 8, No. 1, 2007, p. 31-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Erythropoietin does not preserve motor neurons in a mouse model of familiai ALS
AU - Grignaschi, Giuliano
AU - Zennaro, Eleonora
AU - Tortarolo, Massimo
AU - Calvaresi, Novella
AU - Bendotti, Caterina
PY - 2007
Y1 - 2007
N2 - Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the human Cu/Zn dependent-superoxide dismutase with G93A mutation (SOD1G93A), a model of familial amyotrophic lateral sclerosis. rHuEPO (4 unit/g BW s.c. three times/week), increased the haematocrit and induced a slight delay in impairment of motor function as measured by the rotating bar test. However, it did not prolong life span or reduce motor neuron loss in lumbar spinal cord. The effect on motor function may be due to the improvement of skeletal muscle oxygenation induced by chronic EPO administration.
AB - Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the human Cu/Zn dependent-superoxide dismutase with G93A mutation (SOD1G93A), a model of familial amyotrophic lateral sclerosis. rHuEPO (4 unit/g BW s.c. three times/week), increased the haematocrit and induced a slight delay in impairment of motor function as measured by the rotating bar test. However, it did not prolong life span or reduce motor neuron loss in lumbar spinal cord. The effect on motor function may be due to the improvement of skeletal muscle oxygenation induced by chronic EPO administration.
KW - Amyotrophic lateral sclerosis
KW - Erythropoietin
KW - Motor neuron
KW - Transgenic SOD1G93A mice
UR - http://www.scopus.com/inward/record.url?scp=33847312667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847312667&partnerID=8YFLogxK
U2 - 10.1080/17482960600783456
DO - 10.1080/17482960600783456
M3 - Article
VL - 8
SP - 31
EP - 35
JO - Amyotrophic Lateral Sclerosis
JF - Amyotrophic Lateral Sclerosis
SN - 1748-2968
IS - 1
ER -