Erythropoietin does not preserve motor neurons in a mouse model of familiai ALS

Giuliano Grignaschi, Eleonora Zennaro, Massimo Tortarolo, Novella Calvaresi, Caterina Bendotti

Research output: Contribution to journalArticlepeer-review

Abstract

Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the human Cu/Zn dependent-superoxide dismutase with G93A mutation (SOD1G93A), a model of familial amyotrophic lateral sclerosis. rHuEPO (4 unit/g BW s.c. three times/week), increased the haematocrit and induced a slight delay in impairment of motor function as measured by the rotating bar test. However, it did not prolong life span or reduce motor neuron loss in lumbar spinal cord. The effect on motor function may be due to the improvement of skeletal muscle oxygenation induced by chronic EPO administration.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalAmyotrophic Lateral Sclerosis
Volume8
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • Amyotrophic lateral sclerosis
  • Erythropoietin
  • Motor neuron
  • Transgenic SOD1G93A mice

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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