Erythropoietin is involved in angiogenesis in human primary melanoma

Domenico Ribatti, Beatrice Nico, Maria Teresa Perra, Vito Longo, Cristina Maxia, Tiziana Annese, Franca Piras, Daniela Murtas, Paola Sirigu

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis and tumour thickness. These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalInternational Journal of Experimental Pathology
Volume91
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Angiogenesis
  • Epo
  • EpoR
  • Melanoma
  • Tumour growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

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