Erythropoietin treatment of idiopathic myelofibrosis

M. A. Aloe Spiriti, R. Latagliata, G. Avvisati, V. Battistel, E. Montefusco, A. Spadea, M. C. Petti

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background. In order to determine whether recombinant human erythropoietin (rHuEPO) may play a role in treating anemia in idiopathic myelofibrosis (IMF), a pilot study using high doses of rHuEPO was conducted on patients with IMF. Methods and results. From September, 1990 to December, 1992, 7 patients (6 males and 1 female, median age 68 years) affected by IMF entered the trial. RHuEPO was administered subcutaneously 5 days a week at a dosage of 160 U/kg daily for three mouths. Out of 7 patients, 4 obtained a response. These responders received additional maintenance treatment with rHuEPO until relapse. Response duration was 6, 7, 10+, and 16 months, respectively. Treatment was well-tolerated. Conclusions. Our data suggest that rHuEPO may play a role in the treatment of anemia in some IMF patients.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalHaematologica
Volume78
Issue number6
Publication statusPublished - 1993

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Primary Myelofibrosis
Erythropoietin
Anemia
Therapeutics
Mouth
Recurrence

Keywords

  • erythropoietin
  • idiopathic myelofibrosis

ASJC Scopus subject areas

  • Hematology

Cite this

Aloe Spiriti, M. A., Latagliata, R., Avvisati, G., Battistel, V., Montefusco, E., Spadea, A., & Petti, M. C. (1993). Erythropoietin treatment of idiopathic myelofibrosis. Haematologica, 78(6), 371-373.

Erythropoietin treatment of idiopathic myelofibrosis. / Aloe Spiriti, M. A.; Latagliata, R.; Avvisati, G.; Battistel, V.; Montefusco, E.; Spadea, A.; Petti, M. C.

In: Haematologica, Vol. 78, No. 6, 1993, p. 371-373.

Research output: Contribution to journalArticle

Aloe Spiriti, MA, Latagliata, R, Avvisati, G, Battistel, V, Montefusco, E, Spadea, A & Petti, MC 1993, 'Erythropoietin treatment of idiopathic myelofibrosis', Haematologica, vol. 78, no. 6, pp. 371-373.
Aloe Spiriti MA, Latagliata R, Avvisati G, Battistel V, Montefusco E, Spadea A et al. Erythropoietin treatment of idiopathic myelofibrosis. Haematologica. 1993;78(6):371-373.
Aloe Spiriti, M. A. ; Latagliata, R. ; Avvisati, G. ; Battistel, V. ; Montefusco, E. ; Spadea, A. ; Petti, M. C. / Erythropoietin treatment of idiopathic myelofibrosis. In: Haematologica. 1993 ; Vol. 78, No. 6. pp. 371-373.
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