Erythropoietin treatment of idiopathic myelofibrosis

M. A. Aloe Spiriti, R. Latagliata, G. Avvisati, V. Battistel, E. Montefusco, A. Spadea, M. C. Petti

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Background. In order to determine whether recombinant human erythropoietin (rHuEPO) may play a role in treating anemia in idiopathic myelofibrosis (IMF), a pilot study using high doses of rHuEPO was conducted on patients with IMF. Methods and results. From September, 1990 to December, 1992, 7 patients (6 males and 1 female, median age 68 years) affected by IMF entered the trial. RHuEPO was administered subcutaneously 5 days a week at a dosage of 160 U/kg daily for three mouths. Out of 7 patients, 4 obtained a response. These responders received additional maintenance treatment with rHuEPO until relapse. Response duration was 6, 7, 10+, and 16 months, respectively. Treatment was well-tolerated. Conclusions. Our data suggest that rHuEPO may play a role in the treatment of anemia in some IMF patients.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
Issue number6
Publication statusPublished - 1993


  • erythropoietin
  • idiopathic myelofibrosis

ASJC Scopus subject areas

  • Hematology

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    Aloe Spiriti, M. A., Latagliata, R., Avvisati, G., Battistel, V., Montefusco, E., Spadea, A., & Petti, M. C. (1993). Erythropoietin treatment of idiopathic myelofibrosis. Haematologica, 78(6), 371-373.