Escherichia coli

Effect of fosfomycin trometamol on some urovirulence factors

M. R. Gismondo, L. Drago, C. Fassina, M. L. Garlaschi, M. Rosina, A. Lombardi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of our study was to evaluate the interference of fosfomycin trometanol (F.T.), at subinhibitory concentrations (1/4 and 1/8 MICs), on some urovirulence factors of Escherichia coli (12 strains). We tested fimbriae production, adhesion to uroepithelial cells, hydrophobicity, motility and hemolysin production of E. coli grown in the presence or absence of F.T. The strains tested, grown in the presence of F.T. (1/8 MIC), were less capable of adhering to uroepithelial cells, had less hemagglutination and reduced motility. This behavior was enhanced at 1/4 MIC of F.T. The hemolysin production and hydrophobicity properties present in some of our tested strairs also were significantly decreased when the E. coli were grown in the presence of sub-MIC concentrations of F.T. These results suggest that F.T. may be of clinical use as treatment for acute urinary tract infection and in pyelonephritis prophylaxis.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalJournal of Chemotherapy
Volume6
Issue number3
Publication statusPublished - 1994

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Fosfomycin
Tromethamine
Escherichia coli
Hydrophobic and Hydrophilic Interactions
Hemolysin Proteins
Pyelonephritis
Hemagglutination
Urinary Tract Infections
Cell Movement

Keywords

  • E. coli
  • fosfomycin trometamol
  • urovirulence factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

Gismondo, M. R., Drago, L., Fassina, C., Garlaschi, M. L., Rosina, M., & Lombardi, A. (1994). Escherichia coli: Effect of fosfomycin trometamol on some urovirulence factors. Journal of Chemotherapy, 6(3), 167-172.

Escherichia coli : Effect of fosfomycin trometamol on some urovirulence factors. / Gismondo, M. R.; Drago, L.; Fassina, C.; Garlaschi, M. L.; Rosina, M.; Lombardi, A.

In: Journal of Chemotherapy, Vol. 6, No. 3, 1994, p. 167-172.

Research output: Contribution to journalArticle

Gismondo, MR, Drago, L, Fassina, C, Garlaschi, ML, Rosina, M & Lombardi, A 1994, 'Escherichia coli: Effect of fosfomycin trometamol on some urovirulence factors', Journal of Chemotherapy, vol. 6, no. 3, pp. 167-172.
Gismondo MR, Drago L, Fassina C, Garlaschi ML, Rosina M, Lombardi A. Escherichia coli: Effect of fosfomycin trometamol on some urovirulence factors. Journal of Chemotherapy. 1994;6(3):167-172.
Gismondo, M. R. ; Drago, L. ; Fassina, C. ; Garlaschi, M. L. ; Rosina, M. ; Lombardi, A. / Escherichia coli : Effect of fosfomycin trometamol on some urovirulence factors. In: Journal of Chemotherapy. 1994 ; Vol. 6, No. 3. pp. 167-172.
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