ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

Nicole Concin, Xavier Matias-Guiu, Ignace Vergote, David Cibula, Mansoor Raza Mirza, Simone Marnitz, Jonathan Ledermann, Tjalling Bosse, Cyrus Chargari, Anna Fagotti, Christina Fotopoulou, Antonio Gonzalez Martin, Sigurd Lax, Domenica Lorusso, Christian Marth, Philippe Morice, Remi A Nout, Dearbhaile O'Donnell, Denis Querleu, Maria Rosaria RaspolliniJalid Sehouli, Alina Sturdza, Alexandra Taylor, Anneke Westermann, Pauline Wimberger, Nicoletta Colombo, François Planchamp, Carien L Creutzberg

Research output: Contribution to journalArticlepeer-review


A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and the European Society of Pathology (ESP) jointly decided to update these evidence-based guidelines and to cover new topics in order to improve the quality of care for women with endometrial carcinoma across Europe and worldwide. ESGO/ESTRO/ESP nominated an international multidisciplinary development group consisting of practicing clinicians and researchers who have demonstrated leadership and expertise in the care and research of endometrial carcinoma (27 experts across Europe). To ensure that the guidelines are evidence-based, the literature published since 2014, identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the professional experience and consensus of the development group. The guidelines are thus based on the best available evidence and expert agreement. Prior to publication, the guidelines were reviewed by 191 independent international practitioners in cancer care delivery and patient representatives. The guidelines comprehensively cover endometrial carcinoma staging, definition of prognostic risk groups integrating molecular markers, pre- and intra-operative work-up, fertility preservation, management for early, advanced, metastatic, and recurrent disease and palliative treatment. Principles of radiotherapy and pathological evaluation are also defined.

Original languageEnglish
Pages (from-to)327-353
Number of pages27
JournalRadiotherapy and Oncology
Publication statusPublished - Jan 2021


  • Consensus
  • Endometrial Neoplasms/radiotherapy
  • Europe
  • Female
  • Guidelines as Topic
  • Humans
  • Radiation Oncology
  • Risk Factors


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