Esophageal acid exposure on proton pump inhibitors in unselected asymptomatic gastroesophageal reflux disease patients

Ausilia Grigolon, Paolo Cantù, Daniela Savojardo, Dario Conte, Roberto Penagini

Research output: Contribution to journalArticle

Abstract

Background and Aim: Efficacy of proton pump inhibitors (PPIs) on symptoms of gastroesophageal reflux (GER) is supposed to result from normalization of esophageal acid exposure; however, recent data in selected severe patients have challenged this concept. The aim of the study was to investigate 24-hour esophagogastric pH in unselected patients with GER disease in symptomatic remission during PPIs. Methods: Thirty of the 31 consecutive patients with heartburn enrolled achieved adequate symptom control (≤1 heartburn episode/wk) on PPIs o.d. (n=22) or b.d. (n=8); 3 refused pH monitoring, thus 27 tracings were analyzed. Results: Medians (Interquartile Range); Intragastric tracings showed a wide range of inhibition of acid secretion, 61.2% (49.7% to 80.2%) time at pH>4, nocturnal acid breakthrough being shorter (P=0.03) on PPIs b.d. compared with PPIs o.d., 125 minutes (90 to 247) versus 253 minutes (210 to 340). Esophageal acid exposure was 3.3% (1.4% to 7.9%) time at pH5.5%), 7 of whom on PPIs o.d. Patients with increased acid GER on PPIs had a higher prevalence of esophagitis (67% vs. 22%, P

Original languageEnglish
Pages (from-to)969-973
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume42
Issue number9
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Gastroesophageal reflux
  • pH monitoring
  • Proton pump inhibitors

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Esophageal acid exposure on proton pump inhibitors in unselected asymptomatic gastroesophageal reflux disease patients'. Together they form a unique fingerprint.

  • Cite this