Espresso coffee consumption and risk of coronary heart disease in a large Italian cohort

Sara Grioni, Claudia Agnoli, Sabina Sieri, Valeria Pala, Fulvio Ricceri, Giovanna Masala, Calogero Saieva, Salvatore Panico, Amalia Mattiello, Paolo Chiodini, Rosario Tumino, Graziella Frasca, Licia Iacoviello, Amalia de Curtis, Paolo Vineis, Vittorio Krogh

Research output: Contribution to journalArticlepeer-review


Background: The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods: We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. Results: After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1- 2 cups/day, 1.37 (95% CI 1.03-1.82) for >2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend >0.001) compared to reference (>1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption.

Original languageEnglish
Article numbere0126550
JournalPLoS One
Issue number5
Publication statusPublished - May 6 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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