Essential mixed type II cryoglobulinemia in a HCV positive pregnant woman: Case report

S. Alberico, S. Mazza, E. Grimaldi, C. Volpe, S. Guaschino

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Cryoglobulins are a group of proteins with the common property of precipitating from cooled serum. Cooled cryoglobulinemia is a classic disease caused by immune complexes which subside on vessel walls and produce a clinical picture represented by recurrent purpura, asthenia, arthralgias, Raynaud's phenomenon, glomerulonephritis and sensorimotor neuropathy. The authors describe a case of a patient C.M., 37 years old, with cryoglobulinemia, chronic hepatitis C and gravidic cholestasis at 28 weeks' gestation. The clinical picture worsened with the appearance of mild hypertension with proteinuria and hypochromic anaemia. At 31 weeks' the arthralgic symptomatology and pruritus revealed degeneration with an alteration of glycemic profile values and treatment with rapid human insuline was started. The cardiotocography began to be pathologic and a cesarean section was performed; the newborn weighed 1570 g. Cooled cryoglobulinemia is a pathology which worsens in a gravidic state and can impair the outcome of pregnancy.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalClinical and Experimental Obstetrics and Gynecology
Issue number4
Publication statusPublished - 1998


  • Cryoglobulinemia
  • HCV
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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