TY - JOUR
T1 - Essential oils and their main chemical components
T2 - The past 20 years of preclinical studies in Melanoma
AU - Di Martile, Marta
AU - Garzoli, Stefania
AU - Ragno, Rino
AU - Del Bufalo, Donatella
N1 - Funding Information:
M.D.M. is recipient of a fellowship from Italian Foundation for Cancer Research. The manuscript was supported by grants from Italian Association for Cancer Research (DDB, IG 18560); IRCCS Regina Elena National Cancer Institute (MDM, Ricerca Corrente 2018?2019); Progetti di Rilevante Interesse Nazionale 2017 (RR, prot. 2017JL8SRX); Ateneo Sapienza 2019 (RR, prot. RM11916B8876093E) and Ateneo Sapienza 2018 (RR, prot. RM118164361B425B). Acknowledgments: This review is dedicated to the memory of our marvelous and joyful colleague and friend Marianna Desideri, who enthusiastically worked on our project on essential oils before she passed away. We thank Adele Petricca for preparation of the manuscript and Virginia Filacchione for English revision.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.
AB - The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.
KW - Angiogenesis
KW - Apoptosis
KW - Essential oils
KW - Melanoma
KW - Metastasis
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U2 - 10.3390/cancers12092650
DO - 10.3390/cancers12092650
M3 - Review article
AN - SCOPUS:85090908191
VL - 12
SP - 1
EP - 45
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 9
M1 - 2650
ER -