Essential thrombocythemia or chronic idiopathic myelofibrosis? A single-center study based on hematopoieticbone marrow histology

Umberto Gianelli, Claudia Vener, Paola Rafaniello Raviele, Alessia Moro, Federica Savi, Claudio Annaloro, Francesco Somalvico, Franca Radaelli, Vito Franco, Giorgio Lambertenghi Deliliers

Research output: Contribution to journalArticlepeer-review

Abstract

We reviewed a large series of patients with essential thrombocythemia diagnosed on the basis of the Polycythemia Vera Study Group criteria, and reclassified them by evaluating their major morphologic features and clinical course using the World Health Organization classification. The morphologic review of the bone marrow biopsies of 116 patients (44 males and 72 females; aged 19-83 years, median 55 years; median follow-up 121 months) led to 22 cases (19%) being classified as essential thrombocythemia (ET), 24 (21%) as chronic idiopathic myelofibrosis (CIMF)-0, 44 (37%) as CIMF-1, 13 (12%) as CIMF-2, 9 (8%) as latent phase polycythemia vera, and four (3%) as chronic myeloproliferative disorder, unclassifiable. There was a significant difference in the median age of the ET and fibrotic CIMF patients (54.7 ± 13.55 vs. 59.13 ± 15.05 years; P = 0.03). Histologic analysis showed that the simultaneous presence of loose clusters of large/giant megakaryocytes and nuclear hyperlobulation was significantly different between the ET and the prefibrotic CIMF (P

Original languageEnglish
Pages (from-to)1774-1781
Number of pages8
JournalLeukemia and Lymphoma
Volume47
Issue number9
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Bone marrow histology
  • Chronic myeloproliferative disorders

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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