TY - JOUR
T1 - Essential trace elements in amyotrophic lateral sclerosis (ALS)
T2 - Results in a population of a risk area of Italy
AU - Forte, Giovanni
AU - Bocca, Beatrice
AU - Oggiano, Riccardo
AU - Clemente, Simonetta
AU - Asara, Yolande
AU - Sotgiu, Maria Alessandra
AU - Farace, Cristiano
AU - Montella, Andrea
AU - Fois, Alessandro Giuseppe
AU - Malaguarnera, Michele
AU - Pirina, Pietro
AU - Madeddu, Roberto
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Sardinian (Italy) island population has a uniquely high incidence of amyotrophic lateral sclerosis (ALS). Essential trace element levels in blood, hair, and urine of ALS Sardinian patients were investigated in search of valid biomarkers to recognize and predict ALS. Six elements (Ca, Cu, Fe, Mg, Se, and Zn) were measured in 34 patients compared to 30 age- and sex-matched healthy controls by a validated method. Levels of Ca and Cu in blood and of Se and Zn in hair were significantly higher in ALS than in controls, while urinary excretion of Mg and Se was significantly decreased. The selected cut-off concentrations for these biomarkers may distinguish patients with or without ALS with sufficient sensitivity and specificity. Many positive (as Se-Cu and Se-Zn) and negative associations (as Ca-Mg and Ca-Zn) between elements suggested that multiple metals involved in multiple mechanisms have a role in the ALS degeneration.
AB - Sardinian (Italy) island population has a uniquely high incidence of amyotrophic lateral sclerosis (ALS). Essential trace element levels in blood, hair, and urine of ALS Sardinian patients were investigated in search of valid biomarkers to recognize and predict ALS. Six elements (Ca, Cu, Fe, Mg, Se, and Zn) were measured in 34 patients compared to 30 age- and sex-matched healthy controls by a validated method. Levels of Ca and Cu in blood and of Se and Zn in hair were significantly higher in ALS than in controls, while urinary excretion of Mg and Se was significantly decreased. The selected cut-off concentrations for these biomarkers may distinguish patients with or without ALS with sufficient sensitivity and specificity. Many positive (as Se-Cu and Se-Zn) and negative associations (as Ca-Mg and Ca-Zn) between elements suggested that multiple metals involved in multiple mechanisms have a role in the ALS degeneration.
KW - Amyotrophic lateral sclerosis
KW - Biomarkers
KW - Blood
KW - Hair
KW - Trace elements
KW - Urine
UR - http://www.scopus.com/inward/record.url?scp=85020674927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020674927&partnerID=8YFLogxK
U2 - 10.1007/s10072-017-3018-2
DO - 10.1007/s10072-017-3018-2
M3 - Article
AN - SCOPUS:85020674927
VL - 38
SP - 1609
EP - 1615
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 9
ER -