Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy

Giovanni Forte; Beatrice Bocca; Riccardo Oggiano; Simonetta Clemente; Yolande Asara; Maria Alessandra Sotgiu; Cristiano Farace; Andrea Montella; Alessandro Giuseppe Fois; Michele Malaguarnera; Pietro Pirina; Roberto Madeddu

doi:10.1007/s10072-017-3018-2

Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy

Giovanni Forte, Beatrice Bocca, Riccardo Oggiano, Simonetta Clemente, Yolande Asara, Maria Alessandra Sotgiu, Cristiano Farace, Andrea Montella, Alessandro Giuseppe Fois, Michele Malaguarnera, Pietro Pirina, Roberto Madeddu

Istituto Superiore di Sanita'

Research output: Contribution to journal › Article

Abstract

Sardinian (Italy) island population has a uniquely high incidence of amyotrophic lateral sclerosis (ALS). Essential trace element levels in blood, hair, and urine of ALS Sardinian patients were investigated in search of valid biomarkers to recognize and predict ALS. Six elements (Ca, Cu, Fe, Mg, Se, and Zn) were measured in 34 patients compared to 30 age- and sex-matched healthy controls by a validated method. Levels of Ca and Cu in blood and of Se and Zn in hair were significantly higher in ALS than in controls, while urinary excretion of Mg and Se was significantly decreased. The selected cut-off concentrations for these biomarkers may distinguish patients with or without ALS with sufficient sensitivity and specificity. Many positive (as Se-Cu and Se-Zn) and negative associations (as Ca-Mg and Ca-Zn) between elements suggested that multiple metals involved in multiple mechanisms have a role in the ALS degeneration.

Original language	English
Pages (from-to)	1609-1615
Number of pages	7
Journal	Neurological Sciences
Volume	38
Issue number	9
DOIs	https://doi.org/10.1007/s10072-017-3018-2
Publication status	Published - Sep 1 2017

Keywords

Amyotrophic lateral sclerosis
Biomarkers
Blood
Hair
Trace elements
Urine

ASJC Scopus subject areas

Dermatology
Clinical Neurology
Psychiatry and Mental health

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10.1007/s10072-017-3018-2

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Forte, G., Bocca, B., Oggiano, R., Clemente, S., Asara, Y., Sotgiu, M. A., Farace, C., Montella, A., Fois, A. G., Malaguarnera, M., Pirina, P., & Madeddu, R. (2017). Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy. Neurological Sciences, 38(9), 1609-1615. https://doi.org/10.1007/s10072-017-3018-2

Essential trace elements in amyotrophic lateral sclerosis (ALS) : Results in a population of a risk area of Italy. / Forte, Giovanni ; Bocca, Beatrice; Oggiano, Riccardo; Clemente, Simonetta; Asara, Yolande; Sotgiu, Maria Alessandra; Farace, Cristiano; Montella, Andrea; Fois, Alessandro Giuseppe; Malaguarnera, Michele; Pirina, Pietro; Madeddu, Roberto.

In: Neurological Sciences, Vol. 38, No. 9, 01.09.2017, p. 1609-1615.

Research output: Contribution to journal › Article

Forte, Giovanni ; Bocca, Beatrice ; Oggiano, Riccardo ; Clemente, Simonetta ; Asara, Yolande ; Sotgiu, Maria Alessandra ; Farace, Cristiano ; Montella, Andrea ; Fois, Alessandro Giuseppe ; Malaguarnera, Michele ; Pirina, Pietro ; Madeddu, Roberto. / Essential trace elements in amyotrophic lateral sclerosis (ALS) : Results in a population of a risk area of Italy. In: Neurological Sciences. 2017 ; Vol. 38, No. 9. pp. 1609-1615.

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