Essential tremor is not associated with α-synuclein gene haplotypes

Simona Pigullo, Emilio Di Maria, Roberta Marchese, Emilia Bellone, Rossella Gulli, Cesa Scaglione, Stella Battaglia, Paolo Barone, Paolo Martinelli, Giovanni Abbruzzesse, Franco Ajmar, Paola Mandich

Research output: Contribution to journalArticle

Abstract

A specific allele of the NACP-Rep1 polymorphism within the α-synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the α-synuclein gene. Our results did not confirm the association reported previously and failed to identify a α-synuclein specific haplotype as susceptibility factor for essential tremor.

Original languageEnglish
Pages (from-to)823-826
Number of pages4
JournalMovement Disorders
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

Keywords

  • α-synuclein
  • Association study
  • Essential tremor
  • ET
  • NACP

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Pigullo, S., Di Maria, E., Marchese, R., Bellone, E., Gulli, R., Scaglione, C., Battaglia, S., Barone, P., Martinelli, P., Abbruzzesse, G., Ajmar, F., & Mandich, P. (2003). Essential tremor is not associated with α-synuclein gene haplotypes. Movement Disorders, 18(7), 823-826. https://doi.org/10.1002/mds.10421