Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons

L. Ryom, C. Boesecke, V. Gisler, C. Manzardo, J. K. Rockstroh, M. Puoti, H. Furrer, J. M. Miro, J. M. Gatell, A. Pozniak, G. Behrens, M. Battegay, J. D. Lundgren, Christian Manzardo, Antonella d Arminio Monforte, José Arribas, Nathan Clumeck, Nikos Dedes, Anna Maria Geretti, Andrzej HorbanChristina Katlama, Sheena McCormack, Jean Michel Molina, Cristina Mussini, François Raffi, Peter Reiss, Hans Jürgen Stellbrink, Georg Behrens, Mark Bower, Paola Cinque, Simon Collins, Juliet Compston, Gilbert Deray, Stéphane De Wit, Christoph A. Fux, Giovanni Guraldi, Patrick Mallon, Esteban Martinez, Catia Marzolini, Socrates Papapoulos, Renaud du Pasquier, Neil Poulter, Ian Williams, Alan Winston, Massimo Puoti, Christoph Boesecke, Sanjay Bhagani, Raffaele Bruno, Svilen Konov, Karine Lacombe, Stefan Mauss, Luis Mendao, Lars Peters, Andri Rauch, Cristina Tural, Hansjakob Furrer, Jose M. Miro, Valentin Gisler, Gerd Fätkenheuer, Ole Kirk, Amanda Mocroft, Philippe Morlat, Alain Volny-Anne, Fiona Mulcahy, Christine Katlama, Cristiana Oprea, Mike Youle

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. Guideline highlights: The 2015 version of the EACS guidelines contains major revisions in all sections; antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Among the key revisions is the recommendation of ART for all HIV-positive persons, irrespectively of CD4 count, based on the Strategic Timing of AntiRetroviral Treatment (START) study results. The recommendations for the preferred and the alternative ART options have also been revised, and a new section on the use of pre-exposure prophylaxis (PrEP) has been added. A number of new antiretroviral drugs/drug combinations have been added to the updated tables on drug-drug interactions, adverse drug effects, dose adjustment for renal/liver insufficiency and for ART administration in persons with swallowing difficulties. The revisions of the coinfection section reflect the major advances in anti-hepatitis C virus (HCV) treatment with direct-acting antivirals with earlier start of treatment in individuals at increased risk of liver disease progression, and a phasing out of interferon-containing treatment regimens. The section on opportunistic diseases has been restructured according to individual pathogens/diseases and a new overview table has been added on CD4 count thresholds for different primary prophylaxes. Conclusions: The diagnosis and management of HIV infection and related coinfections, opportunistic diseases and comorbidities continue to require a multidisciplinary effort for which the 2015 version of the EACS guidelines provides an easily accessable and updated overview.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalHIV Medicine
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Antiretroviral treatment
  • ART
  • Comorbidities
  • EACS
  • Guidelines
  • HBV
  • HCV
  • HIV
  • Opportunistic infections

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Health Policy

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