Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons

L. Ryom, Christoph Boesecke, V. Gisler, Christian Manzardo, J. Rockstroh, M. Puoti, Hansjakob Furrer, Jose Miro, J. M. Gatell, A. Pozniak, G. Behrens, Manuel Battegay, J. D. Lundgren, Christian Manzardo, Antonella D Arminio Monforte, José Arribas, Nathan Clumeck, N. Dedes, Anna Maria Geretti, A. HorbanChristina Katlama, Sheena McCormack, Jean Michel Molina, Cristina Mussini, F. Raffi, Peter Reiss, H. J. Stellbrink, Georg Behrens, Mark Bower, Paola Cinque, Simon Collins, Juliet Compston, Gilbert Deray, Stéphane De Wit, Christoph A. Fux, Giovanni Guraldi, Patrick W. Mallon, Esteban Martinez, C. Marzolini, S. Papapoulos, Renaud du Pasquier, Neil Poulter, I. Williams, Alan Winston, M. Puoti, Christoph Boesecke, S. Bhagani, Raffaele Bruno, Svilen Konov, K. Lacombe, Stefan Mauss, L. Mendao, L. Peters, Andri Rauch, C. Tural, Hansjakob Furrer, Jose M. Miro, Valentin Gisler, Gerd Fätkenheuer, O. Kirk, Amanda Mocroft, P. Morlat, Alain Volny-Anne, F. Mulcahy, Christine Katlama, C. Oprea, M. Youle

Research output: Contribution to journalArticle

Abstract

Background: The European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. Guideline highlights: The 2015 version of the EACS guidelines contains major revisions in all sections; antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Among the key revisions is the recommendation of ART for all HIV-positive persons, irrespectively of CD4 count, based on the Strategic Timing of AntiRetroviral Treatment (START) study results. The recommendations for the preferred and the alternative ART options have also been revised, and a new section on the use of pre-exposure prophylaxis (PrEP) has been added. A number of new antiretroviral drugs/drug combinations have been added to the updated tables on drug-drug interactions, adverse drug effects, dose adjustment for renal/liver insufficiency and for ART administration in persons with swallowing difficulties. The revisions of the coinfection section reflect the major advances in anti-hepatitis C virus (HCV) treatment with direct-acting antivirals with earlier start of treatment in individuals at increased risk of liver disease progression, and a phasing out of interferon-containing treatment regimens. The section on opportunistic diseases has been restructured according to individual pathogens/diseases and a new overview table has been added on CD4 count thresholds for different primary prophylaxes. Conclusions: The diagnosis and management of HIV infection and related coinfections, opportunistic diseases and comorbidities continue to require a multidisciplinary effort for which the 2015 version of the EACS guidelines provides an easily accessable and updated overview.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalHIV Medicine
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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Acquired Immunodeficiency Syndrome
Coinfection
HIV
Guidelines
CD4 Lymphocyte Count
Comorbidity
AIDS-Related Opportunistic Infections
Pharmaceutical Preparations
Hepatic Insufficiency
Drug Combinations
Deglutition
Drug Interactions
Hepacivirus
Interferons
Renal Insufficiency
Antiviral Agents
Disease Progression
Liver Diseases

Keywords

  • Antiretroviral treatment
  • ART
  • Comorbidities
  • EACS
  • Guidelines
  • HBV
  • HCV
  • HIV
  • Opportunistic infections

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Health Policy

Cite this

Ryom, L., Boesecke, C., Gisler, V., Manzardo, C., Rockstroh, J., Puoti, M., ... Youle, M. (2016). Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. HIV Medicine, 17(2), 83-88. https://doi.org/10.1111/hiv.12322

Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. / Ryom, L.; Boesecke, Christoph; Gisler, V.; Manzardo, Christian; Rockstroh, J.; Puoti, M.; Furrer, Hansjakob; Miro, Jose; Gatell, J. M.; Pozniak, A.; Behrens, G.; Battegay, Manuel; Lundgren, J. D.; Manzardo, Christian; Monforte, Antonella D Arminio; Arribas, José; Clumeck, Nathan; Dedes, N.; Geretti, Anna Maria; Horban, A.; Katlama, Christina; McCormack, Sheena; Molina, Jean Michel; Mussini, Cristina; Raffi, F.; Reiss, Peter; Stellbrink, H. J.; Behrens, Georg; Bower, Mark; Cinque, Paola; Collins, Simon; Compston, Juliet; Deray, Gilbert; De Wit, Stéphane; Fux, Christoph A.; Guraldi, Giovanni; Mallon, Patrick W.; Martinez, Esteban; Marzolini, C.; Papapoulos, S.; du Pasquier, Renaud; Poulter, Neil; Williams, I.; Winston, Alan; Puoti, M.; Boesecke, Christoph; Bhagani, S.; Bruno, Raffaele; Konov, Svilen; Lacombe, K.; Mauss, Stefan; Mendao, L.; Peters, L.; Rauch, Andri; Tural, C.; Furrer, Hansjakob; Miro, Jose M.; Gisler, Valentin; Fätkenheuer, Gerd; Kirk, O.; Mocroft, Amanda; Morlat, P.; Volny-Anne, Alain; Mulcahy, F.; Katlama, Christine; Oprea, C.; Youle, M.

In: HIV Medicine, Vol. 17, No. 2, 01.02.2016, p. 83-88.

Research output: Contribution to journalArticle

Ryom, L, Boesecke, C, Gisler, V, Manzardo, C, Rockstroh, J, Puoti, M, Furrer, H, Miro, J, Gatell, JM, Pozniak, A, Behrens, G, Battegay, M, Lundgren, JD, Manzardo, C, Monforte, ADA, Arribas, J, Clumeck, N, Dedes, N, Geretti, AM, Horban, A, Katlama, C, McCormack, S, Molina, JM, Mussini, C, Raffi, F, Reiss, P, Stellbrink, HJ, Behrens, G, Bower, M, Cinque, P, Collins, S, Compston, J, Deray, G, De Wit, S, Fux, CA, Guraldi, G, Mallon, PW, Martinez, E, Marzolini, C, Papapoulos, S, du Pasquier, R, Poulter, N, Williams, I, Winston, A, Puoti, M, Boesecke, C, Bhagani, S, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendao, L, Peters, L, Rauch, A, Tural, C, Furrer, H, Miro, JM, Gisler, V, Fätkenheuer, G, Kirk, O, Mocroft, A, Morlat, P, Volny-Anne, A, Mulcahy, F, Katlama, C, Oprea, C & Youle, M 2016, 'Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons', HIV Medicine, vol. 17, no. 2, pp. 83-88. https://doi.org/10.1111/hiv.12322
Ryom, L. ; Boesecke, Christoph ; Gisler, V. ; Manzardo, Christian ; Rockstroh, J. ; Puoti, M. ; Furrer, Hansjakob ; Miro, Jose ; Gatell, J. M. ; Pozniak, A. ; Behrens, G. ; Battegay, Manuel ; Lundgren, J. D. ; Manzardo, Christian ; Monforte, Antonella D Arminio ; Arribas, José ; Clumeck, Nathan ; Dedes, N. ; Geretti, Anna Maria ; Horban, A. ; Katlama, Christina ; McCormack, Sheena ; Molina, Jean Michel ; Mussini, Cristina ; Raffi, F. ; Reiss, Peter ; Stellbrink, H. J. ; Behrens, Georg ; Bower, Mark ; Cinque, Paola ; Collins, Simon ; Compston, Juliet ; Deray, Gilbert ; De Wit, Stéphane ; Fux, Christoph A. ; Guraldi, Giovanni ; Mallon, Patrick W. ; Martinez, Esteban ; Marzolini, C. ; Papapoulos, S. ; du Pasquier, Renaud ; Poulter, Neil ; Williams, I. ; Winston, Alan ; Puoti, M. ; Boesecke, Christoph ; Bhagani, S. ; Bruno, Raffaele ; Konov, Svilen ; Lacombe, K. ; Mauss, Stefan ; Mendao, L. ; Peters, L. ; Rauch, Andri ; Tural, C. ; Furrer, Hansjakob ; Miro, Jose M. ; Gisler, Valentin ; Fätkenheuer, Gerd ; Kirk, O. ; Mocroft, Amanda ; Morlat, P. ; Volny-Anne, Alain ; Mulcahy, F. ; Katlama, Christine ; Oprea, C. ; Youle, M. / Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. In: HIV Medicine. 2016 ; Vol. 17, No. 2. pp. 83-88.
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T1 - Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons

AU - Ryom, L.

AU - Boesecke, Christoph

AU - Gisler, V.

AU - Manzardo, Christian

AU - Rockstroh, J.

AU - Puoti, M.

AU - Furrer, Hansjakob

AU - Miro, Jose

AU - Gatell, J. M.

AU - Pozniak, A.

AU - Behrens, G.

AU - Battegay, Manuel

AU - Lundgren, J. D.

AU - Manzardo, Christian

AU - Monforte, Antonella D Arminio

AU - Arribas, José

AU - Clumeck, Nathan

AU - Dedes, N.

AU - Geretti, Anna Maria

AU - Horban, A.

AU - Katlama, Christina

AU - McCormack, Sheena

AU - Molina, Jean Michel

AU - Mussini, Cristina

AU - Raffi, F.

AU - Reiss, Peter

AU - Stellbrink, H. J.

AU - Behrens, Georg

AU - Bower, Mark

AU - Cinque, Paola

AU - Collins, Simon

AU - Compston, Juliet

AU - Deray, Gilbert

AU - De Wit, Stéphane

AU - Fux, Christoph A.

AU - Guraldi, Giovanni

AU - Mallon, Patrick W.

AU - Martinez, Esteban

AU - Marzolini, C.

AU - Papapoulos, S.

AU - du Pasquier, Renaud

AU - Poulter, Neil

AU - Williams, I.

AU - Winston, Alan

AU - Puoti, M.

AU - Boesecke, Christoph

AU - Bhagani, S.

AU - Bruno, Raffaele

AU - Konov, Svilen

AU - Lacombe, K.

AU - Mauss, Stefan

AU - Mendao, L.

AU - Peters, L.

AU - Rauch, Andri

AU - Tural, C.

AU - Furrer, Hansjakob

AU - Miro, Jose M.

AU - Gisler, Valentin

AU - Fätkenheuer, Gerd

AU - Kirk, O.

AU - Mocroft, Amanda

AU - Morlat, P.

AU - Volny-Anne, Alain

AU - Mulcahy, F.

AU - Katlama, Christine

AU - Oprea, C.

AU - Youle, M.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: The European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. Guideline highlights: The 2015 version of the EACS guidelines contains major revisions in all sections; antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Among the key revisions is the recommendation of ART for all HIV-positive persons, irrespectively of CD4 count, based on the Strategic Timing of AntiRetroviral Treatment (START) study results. The recommendations for the preferred and the alternative ART options have also been revised, and a new section on the use of pre-exposure prophylaxis (PrEP) has been added. A number of new antiretroviral drugs/drug combinations have been added to the updated tables on drug-drug interactions, adverse drug effects, dose adjustment for renal/liver insufficiency and for ART administration in persons with swallowing difficulties. The revisions of the coinfection section reflect the major advances in anti-hepatitis C virus (HCV) treatment with direct-acting antivirals with earlier start of treatment in individuals at increased risk of liver disease progression, and a phasing out of interferon-containing treatment regimens. The section on opportunistic diseases has been restructured according to individual pathogens/diseases and a new overview table has been added on CD4 count thresholds for different primary prophylaxes. Conclusions: The diagnosis and management of HIV infection and related coinfections, opportunistic diseases and comorbidities continue to require a multidisciplinary effort for which the 2015 version of the EACS guidelines provides an easily accessable and updated overview.

AB - Background: The European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. Guideline highlights: The 2015 version of the EACS guidelines contains major revisions in all sections; antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Among the key revisions is the recommendation of ART for all HIV-positive persons, irrespectively of CD4 count, based on the Strategic Timing of AntiRetroviral Treatment (START) study results. The recommendations for the preferred and the alternative ART options have also been revised, and a new section on the use of pre-exposure prophylaxis (PrEP) has been added. A number of new antiretroviral drugs/drug combinations have been added to the updated tables on drug-drug interactions, adverse drug effects, dose adjustment for renal/liver insufficiency and for ART administration in persons with swallowing difficulties. The revisions of the coinfection section reflect the major advances in anti-hepatitis C virus (HCV) treatment with direct-acting antivirals with earlier start of treatment in individuals at increased risk of liver disease progression, and a phasing out of interferon-containing treatment regimens. The section on opportunistic diseases has been restructured according to individual pathogens/diseases and a new overview table has been added on CD4 count thresholds for different primary prophylaxes. Conclusions: The diagnosis and management of HIV infection and related coinfections, opportunistic diseases and comorbidities continue to require a multidisciplinary effort for which the 2015 version of the EACS guidelines provides an easily accessable and updated overview.

KW - Antiretroviral treatment

KW - ART

KW - Comorbidities

KW - EACS

KW - Guidelines

KW - HBV

KW - HCV

KW - HIV

KW - Opportunistic infections

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