Establishment and characterization of a leukemic murine cell line derived from MCF 247 MuLV-induced T-cell lymphoma

R. Dolcetti, A. Carbone, S. Barlati, R. Maestro, S. Rizzo, F. Sonego, G. Feriotto, D. Bellotti, M. Boiocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding of the leukemic evolution of human non-Hodgkin's lymphomas is hindered by the lack of appropriate animal models. For this purpose, a highly leukemic cell line NQ22, derived from a MCF 247 murine leukemia virus (MuLV)-induced murine T-cell lymphoma, was established, and its preliminary characterization is described. The NQ22 cell line is easily transplantable subcutaneously (s.c.) into syngeneic AKR mice exhibiting early peripheral blood invasion and widespread dissemination with a leukemic pattern of infiltration. Such peculiar in vivo behavior is a stable phenotypic feature, probably determined genetically. Biological and differentiation characteristics of the NQ22 cell line were analyzed and compared to those of other non-leukemic T-lymphoma lines. In addition, no evidence of possible involvement of plasminogen activator (PA) enzymes and of their inhibitors (PAI) in the spreading ability of NQ22 cells was observed.

Original languageEnglish
Pages (from-to)928-934
Number of pages7
JournalInternational Journal of Cancer
Volume45
Issue number5
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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