Establishment of a new Epstein-Barr virus-immortalized cell line from chronic lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen

M. Crescenzi, M. Napolitano, M. Carbonari, A. Antonelli, P. Petrinelli, C. Gaetano, M. Fiorilli

Research output: Contribution to journalArticlepeer-review

Abstract

Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid cell line was obtained by immortalization of leukemic cells with Epstein-Barr virus (EBV). Cultured leukemic cells were found to have a supernumerary chromosome 12, an abnormality typical of CLL of the B cell type. To our knowledge, this is the first EBV-immortalized cell line from B-CLL cells of known SRBC specificity and the third reported CLL cell line carrying trisomy of chromosome 12.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalBlood
Volume71
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology

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