Abstract

To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments’ responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database—shortly including many other Italian headache centers—will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.
Original languageEnglish
Pages (from-to)933-937
Number of pages5
JournalNeurological Sciences
Volume39
Issue number5
DOIs
Publication statusPublished - May 1 2018

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Migraine Disorders
Multicenter Studies
Databases
Endophenotypes
Resource Allocation
Headache
Economics
Delivery of Health Care
Registries
Life Style
Hospital Emergency Service
Comorbidity
Demography
Interviews
Phenotype
Health
Therapeutics

Keywords

  • Chronic migraine
  • Database
  • Disability
  • Epidemiology
  • Migraine burden
  • Registry

Cite this

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title = "Establishment of an Italian chronic migraine database: a multicenter pilot study",
abstract = "To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments’ responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database—shortly including many other Italian headache centers—will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.",
keywords = "Chronic migraine, Database, Disability, Epidemiology, Migraine burden, Registry",
author = "Piero Barbanti and L. Fofi and S. Cevoli and P. Torelli and C. Aurilia and G. Egeo and L. Grazzi and D. D’Amico and Manzoni, {G. C.} and P. Cortelli and F. Infarinato and N. Vanacore",
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T1 - Establishment of an Italian chronic migraine database: a multicenter pilot study

AU - Barbanti, Piero

AU - Fofi, L.

AU - Cevoli, S.

AU - Torelli, P.

AU - Aurilia, C.

AU - Egeo, G.

AU - Grazzi, L.

AU - D’Amico, D.

AU - Manzoni, G. C.

AU - Cortelli, P.

AU - Infarinato, F.

AU - Vanacore, N.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments’ responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database—shortly including many other Italian headache centers—will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.

AB - To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments’ responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database—shortly including many other Italian headache centers—will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.

KW - Chronic migraine

KW - Database

KW - Disability

KW - Epidemiology

KW - Migraine burden

KW - Registry

U2 - 10.1007/s10072-018-3280-y

DO - 10.1007/s10072-018-3280-y

M3 - Article

VL - 39

SP - 933

EP - 937

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

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ER -