Estimate of overdiagnosis of breast cancer due to mammography after adjustment for lead time. A service screening study in Italy

Eugenio Paci, Guido Miccinesi, Donella Puliti, Paola Baldazzi, Vincenzo De Lisi, Fabio Falcini, Claudia Cirilli, Stefano Ferretti, Lucia Mangone, Alba Finarelli, Stefano Rosso, Nereo Segnan, Fabrizio Stracci, Adele Traina, Rosario Tumino, Manuel Zorzi

Research output: Contribution to journalArticle

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Abstract

Introduction: Excess of incidence rates is the expected consequence of service screening. The aim of this paper is to estimate the quota attributable to overdiagnosis in the breast cancer screening programmes in Northern and Central Italy. Methods: All patients with breast cancer diagnosed between 50 and 74 years who were resident in screening areas in the six years before and five years after the start of the screening programme were included. We calculated a corrected-for-lead-time number of observed cases for each calendar year. The number of observed incident cases was reduced by the number of screen-detected cases in that year and incremented by the estimated number of screen-detected cases that would have arisen clinically in that year. Results: In total we included 13,519 and 13,999 breast cancer cases diagnosed in the pre-screening and screening years, respectively. In total, the excess ratio of observed to predicted in situ and invasive cases was 36.2%. After correction for lead time the excess ratio was 4.6% (95% confidence interval 2 to 7%) and for invasive cases only it was 3.2% (95% confidence interval 1 to 6%). Conclusion: The remaining excess of cancers after individual correction for lead time was lower than 5%.

Original languageEnglish
Article numberR68
JournalBreast Cancer Research
Volume8
Issue number6
DOIs
Publication statusPublished - Dec 5 2006

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Mammography
Italy
Breast Neoplasms
Confidence Intervals
Early Detection of Cancer
Incidence
Medical Overuse
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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Estimate of overdiagnosis of breast cancer due to mammography after adjustment for lead time. A service screening study in Italy. / Paci, Eugenio; Miccinesi, Guido; Puliti, Donella; Baldazzi, Paola; De Lisi, Vincenzo; Falcini, Fabio; Cirilli, Claudia; Ferretti, Stefano; Mangone, Lucia; Finarelli, Alba; Rosso, Stefano; Segnan, Nereo; Stracci, Fabrizio; Traina, Adele; Tumino, Rosario; Zorzi, Manuel.

In: Breast Cancer Research, Vol. 8, No. 6, R68, 05.12.2006.

Research output: Contribution to journalArticle

Paci, E, Miccinesi, G, Puliti, D, Baldazzi, P, De Lisi, V, Falcini, F, Cirilli, C, Ferretti, S, Mangone, L, Finarelli, A, Rosso, S, Segnan, N, Stracci, F, Traina, A, Tumino, R & Zorzi, M 2006, 'Estimate of overdiagnosis of breast cancer due to mammography after adjustment for lead time. A service screening study in Italy', Breast Cancer Research, vol. 8, no. 6, R68. https://doi.org/10.1186/bcr1625
Paci, Eugenio ; Miccinesi, Guido ; Puliti, Donella ; Baldazzi, Paola ; De Lisi, Vincenzo ; Falcini, Fabio ; Cirilli, Claudia ; Ferretti, Stefano ; Mangone, Lucia ; Finarelli, Alba ; Rosso, Stefano ; Segnan, Nereo ; Stracci, Fabrizio ; Traina, Adele ; Tumino, Rosario ; Zorzi, Manuel. / Estimate of overdiagnosis of breast cancer due to mammography after adjustment for lead time. A service screening study in Italy. In: Breast Cancer Research. 2006 ; Vol. 8, No. 6.
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AU - De Lisi, Vincenzo

AU - Falcini, Fabio

AU - Cirilli, Claudia

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AU - Mangone, Lucia

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AU - Rosso, Stefano

AU - Segnan, Nereo

AU - Stracci, Fabrizio

AU - Traina, Adele

AU - Tumino, Rosario

AU - Zorzi, Manuel

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N2 - Introduction: Excess of incidence rates is the expected consequence of service screening. The aim of this paper is to estimate the quota attributable to overdiagnosis in the breast cancer screening programmes in Northern and Central Italy. Methods: All patients with breast cancer diagnosed between 50 and 74 years who were resident in screening areas in the six years before and five years after the start of the screening programme were included. We calculated a corrected-for-lead-time number of observed cases for each calendar year. The number of observed incident cases was reduced by the number of screen-detected cases in that year and incremented by the estimated number of screen-detected cases that would have arisen clinically in that year. Results: In total we included 13,519 and 13,999 breast cancer cases diagnosed in the pre-screening and screening years, respectively. In total, the excess ratio of observed to predicted in situ and invasive cases was 36.2%. After correction for lead time the excess ratio was 4.6% (95% confidence interval 2 to 7%) and for invasive cases only it was 3.2% (95% confidence interval 1 to 6%). Conclusion: The remaining excess of cancers after individual correction for lead time was lower than 5%.

AB - Introduction: Excess of incidence rates is the expected consequence of service screening. The aim of this paper is to estimate the quota attributable to overdiagnosis in the breast cancer screening programmes in Northern and Central Italy. Methods: All patients with breast cancer diagnosed between 50 and 74 years who were resident in screening areas in the six years before and five years after the start of the screening programme were included. We calculated a corrected-for-lead-time number of observed cases for each calendar year. The number of observed incident cases was reduced by the number of screen-detected cases in that year and incremented by the estimated number of screen-detected cases that would have arisen clinically in that year. Results: In total we included 13,519 and 13,999 breast cancer cases diagnosed in the pre-screening and screening years, respectively. In total, the excess ratio of observed to predicted in situ and invasive cases was 36.2%. After correction for lead time the excess ratio was 4.6% (95% confidence interval 2 to 7%) and for invasive cases only it was 3.2% (95% confidence interval 1 to 6%). Conclusion: The remaining excess of cancers after individual correction for lead time was lower than 5%.

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