Estimate of renal function in oldest old inpatients by MDRD study equation, Mayo Clinic equation and creatinine clearance

Vincenzo Carnevale, Luca Pastore, Marcello Camaioni, Monica Mellozzi, Massimo Sabatini, Elisabetta Arietti, Saverio Fusilli, Alfredo Scillitani, Mario Pontecorvi

Research output: Contribution to journalArticle

Abstract

Background: Patients older than 85 years are increasingly admitted to hospital care settings. Despite this, the clinical employment of equations for estimating glomerular filtration rate (GFR) has been scarcely investigated so far in this age group. Our study compared 2 commonly employed equations to estimate GFR, as well as measured 24-hour creatinine clearance (CrCl), in patients aged ≥85 years. Methods: Seventy-three patients consecutively admitted over 4 months to our Internal Medicine Department had an accurate 24-hour urinary collection, as well as serum and urinary creatinine determinations. Measured CrCl was compared with the GFR values estimated by the Modification of Diet in Renal Disease (MDRD) Study and Mayo Clinic quadratic (MCQ) equations. Results: GFR values derived by MDRD and MCQ equations and CrCl significantly differed from each other in the whole sample. CrCl negatively correlated with age (r=-0.389, p

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalJournal of Nephrology
Volume23
Issue number3
Publication statusPublished - May 2010

Keywords

  • 24-Hour creatinine clearance
  • Mayo Clinic quadratic equation
  • MDRD equation
  • Oldest old inpatients

ASJC Scopus subject areas

  • Nephrology

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    Carnevale, V., Pastore, L., Camaioni, M., Mellozzi, M., Sabatini, M., Arietti, E., Fusilli, S., Scillitani, A., & Pontecorvi, M. (2010). Estimate of renal function in oldest old inpatients by MDRD study equation, Mayo Clinic equation and creatinine clearance. Journal of Nephrology, 23(3), 306-313.