Estimated glomerular filtration rate and functional status among older people: A systematic review

Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators

Research output: Contribution to journalArticle

Abstract

Background: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. Methods: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. Results: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. Conclusion: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalEuropean Journal of Internal Medicine
Volume56
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Glomerular Filtration Rate
Creatinine
Cystatin C
Hand Strength
Longitudinal Studies
Cross-Sectional Studies
Chronic Renal Insufficiency
PubMed

Keywords

  • Creatinine
  • Cystatin C
  • Disability
  • Estimated glomerular filtration rate (eGFR)
  • Frailty

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators (2018). Estimated glomerular filtration rate and functional status among older people: A systematic review. European Journal of Internal Medicine, 56, 39-48. https://doi.org/10.1016/j.ejim.2018.05.030

Estimated glomerular filtration rate and functional status among older people : A systematic review. / Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators.

In: European Journal of Internal Medicine, Vol. 56, 01.10.2018, p. 39-48.

Research output: Contribution to journalArticle

Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators 2018, 'Estimated glomerular filtration rate and functional status among older people: A systematic review', European Journal of Internal Medicine, vol. 56, pp. 39-48. https://doi.org/10.1016/j.ejim.2018.05.030
Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators. Estimated glomerular filtration rate and functional status among older people: A systematic review. European Journal of Internal Medicine. 2018 Oct 1;56:39-48. https://doi.org/10.1016/j.ejim.2018.05.030
Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators. / Estimated glomerular filtration rate and functional status among older people : A systematic review. In: European Journal of Internal Medicine. 2018 ; Vol. 56. pp. 39-48.
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abstract = "Background: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. Methods: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. Results: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. Conclusion: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.",
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AU - Screening for Chronic Kidney Disease among Older people across Europe (SCOPE) Study Investigators

AU - Corsonello, Andrea

AU - Roller-Wirnsberger, Regina

AU - Di Rosa, Mirko

AU - Fabbietti, Paolo

AU - Wirnsberger, Gerhard

AU - Kostka, Tomasz

AU - Guligowska, Agnieszka

AU - Tap, Lisanne

AU - Mattace-Raso, Francesco

AU - Gil, Pedro

AU - Guardado-Fuentes, Lara

AU - Meltzer, Itshak

AU - Yehoshua, Ilan

AU - Artzi-Medevdik, Rada

AU - Formiga, Francesc

AU - Moreno-González, Rafael

AU - Weingart, Christian

AU - Freiberger, Ellen

AU - Ärnlöv, Johan

AU - Carlsson, Axel C.

AU - Lattanzio, Fabrizia

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N2 - Background: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. Methods: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. Results: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. Conclusion: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.

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KW - Cystatin C

KW - Disability

KW - Estimated glomerular filtration rate (eGFR)

KW - Frailty

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