Estimating dyskinesia severity in Parkinson's disease by using a waist-worn sensor: concurrent validity study

Alejandro Rodríguez-Molinero, Carlos Pérez-López, Albert Samà, Daniel Rodríguez-Martín, Sheila Alcaine, Berta Mestre, Paola Quispe, Benedetta Giuliani, Gabriel Vainstein, Patrick Browne, Dean Sweeney, Leo R. Quinlan, J. Manuel Moreno Arostegui, Àngels Bayes, Hadas Lewy, Alberto Costa, Roberta Annicchiarico, Timothy Counihan, Gearòid Laighin, Joan Cabestany

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Abstract

Our research team previously developed an accelerometry-based device, which can be worn on the waist during daily life activities and detects the occurrence of dyskinesia in patients with Parkinson's disease. The goal of this study was to analyze the magnitude of correlation between the numeric output of the device algorithm and the results of the Unified Dyskinesia Rating Scale (UDysRS), administered by a physician. In this study, 13 Parkinson's patients, who were symptomatic with dyskinesias, were monitored with the device at home, for an average period of 30 minutes, while performing normal daily life activities. Each patient's activity was simultaneously video-recorded. A physician was in charge of reviewing the recorded videos and determining the severity of dyskinesia through the UDysRS for every patient. The sensor device yielded only one value for dyskinesia severity, which was calculated by averaging the recorded device readings. Correlation between the results of physician's assessment and the sensor output was analyzed with the Spearman's correlation coefficient. The correlation coefficient between the sensor output and UDysRS result was 0.70 (CI 95%: 0.33-0.88; p = 0.01). Since the sensor was located on the waist, the correlation between the sensor output and the results of the trunk and legs scale sub-items was calculated: 0.91 (CI 95% 0.76-0.97: p < 0.001). The conclusion is that the magnitude of dyskinesia, as measured by the tested device, presented good correlation with that observed by a physician.

Original languageEnglish
Number of pages1
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Sep 17 2019

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    Rodríguez-Molinero, A., Pérez-López, C., Samà, A., Rodríguez-Martín, D., Alcaine, S., Mestre, B., Quispe, P., Giuliani, B., Vainstein, G., Browne, P., Sweeney, D., Quinlan, L. R., Arostegui, J. M. M., Bayes, À., Lewy, H., Costa, A., Annicchiarico, R., Counihan, T., Laighin, G., & Cabestany, J. (2019). Estimating dyskinesia severity in Parkinson's disease by using a waist-worn sensor: concurrent validity study. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-49798-3