Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions

Cosmo Godino, Davide Maccagni, Anna Giulia Pavon, Giacomo Viani, Alberto Cappelletti, Alberto Margonato, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Minimal data exist on the number of additional cancer cases related to radiation exposure following percutaneous coronary intervention (PCI). The aim of this study is to estimate the lifetime attributable risk (LAR) of cancer incidence for individual organs following radiation exposure during PCI in the context of two opposite sides of the angiographic spectrum of coronary occlusive disease: ST-elevation myocardial infarction (STEMI) and chronic coronary total occlusion (CTO). METHODS AND RESULTS: We identified all consecutive patients treated with PCI for STEMI (n ≤ 555) and for CTO (n ≤ 543) in a tertiary care center in 6 years. The LARs of cancer incidence for 6 organs were estimated using the Biological Effects of Ionizing Radiation (BEIR) VII model. The estimated LAR of cancer incidence for individual organs was found to markedly increase as the age of the patient decreased and was significantly higher for the lung (additional risk up to 18/100,000 persons exposed in CTO and 9/100,000 persons exposed in STEMI patients, respectively; P

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalJournal of Invasive Cardiology
Volume25
Issue number9
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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