Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions

Cosmo Godino; Davide Maccagni; Anna Giulia Pavon; Giacomo Viani; Alberto Cappelletti; Alberto Margonato; Antonio Colombo

Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions

Cosmo Godino, Davide Maccagni, Anna Giulia Pavon, Giacomo Viani, Alberto Cappelletti, Alberto Margonato, Antonio Colombo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Minimal data exist on the number of additional cancer cases related to radiation exposure following percutaneous coronary intervention (PCI). The aim of this study is to estimate the lifetime attributable risk (LAR) of cancer incidence for individual organs following radiation exposure during PCI in the context of two opposite sides of the angiographic spectrum of coronary occlusive disease: ST-elevation myocardial infarction (STEMI) and chronic coronary total occlusion (CTO). METHODS AND RESULTS: We identified all consecutive patients treated with PCI for STEMI (n ≤ 555) and for CTO (n ≤ 543) in a tertiary care center in 6 years. The LARs of cancer incidence for 6 organs were estimated using the Biological Effects of Ionizing Radiation (BEIR) VII model. The estimated LAR of cancer incidence for individual organs was found to markedly increase as the age of the patient decreased and was significantly higher for the lung (additional risk up to 18/100,000 persons exposed in CTO and 9/100,000 persons exposed in STEMI patients, respectively; P

Original language	English
Pages (from-to)	441-445
Number of pages	5
Journal	Journal of Invasive Cardiology
Volume	25
Issue number	9
Publication status	Published - Sep 2013

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

Access to Document

Fingerprint Dive into the research topics of 'Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions'. Together they form a unique fingerprint.

Cite this

Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions. / Godino, Cosmo; Maccagni, Davide; Pavon, Anna Giulia; Viani, Giacomo; Cappelletti, Alberto; Margonato, Alberto; Colombo, Antonio.

In: Journal of Invasive Cardiology, Vol. 25, No. 9, 09.2013, p. 441-445.

Research output: Contribution to journal › Article › peer-review

@article{447d297f88974ffba371c78bd5cb3249,

title = "Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions",

abstract = "BACKGROUND: Minimal data exist on the number of additional cancer cases related to radiation exposure following percutaneous coronary intervention (PCI). The aim of this study is to estimate the lifetime attributable risk (LAR) of cancer incidence for individual organs following radiation exposure during PCI in the context of two opposite sides of the angiographic spectrum of coronary occlusive disease: ST-elevation myocardial infarction (STEMI) and chronic coronary total occlusion (CTO). METHODS AND RESULTS: We identified all consecutive patients treated with PCI for STEMI (n ≤ 555) and for CTO (n ≤ 543) in a tertiary care center in 6 years. The LARs of cancer incidence for 6 organs were estimated using the Biological Effects of Ionizing Radiation (BEIR) VII model. The estimated LAR of cancer incidence for individual organs was found to markedly increase as the age of the patient decreased and was significantly higher for the lung (additional risk up to 18/100,000 persons exposed in CTO and 9/100,000 persons exposed in STEMI patients, respectively; P",

author = "Cosmo Godino and Davide Maccagni and Pavon, {Anna Giulia} and Giacomo Viani and Alberto Cappelletti and Alberto Margonato and Antonio Colombo",

year = "2013",

month = sep,

language = "English",

volume = "25",

pages = "441--445",

journal = "Journal of Invasive Cardiology",

issn = "1042-3931",

publisher = "HMP Communications",

number = "9",

}

TY - JOUR

T1 - Estimating incidence of organ cancer related to PCI radiation exposure in patients treated for acute and chronic total occlusions

AU - Godino, Cosmo

AU - Maccagni, Davide

AU - Pavon, Anna Giulia

AU - Viani, Giacomo

AU - Cappelletti, Alberto

AU - Margonato, Alberto

AU - Colombo, Antonio

PY - 2013/9

Y1 - 2013/9

N2 - BACKGROUND: Minimal data exist on the number of additional cancer cases related to radiation exposure following percutaneous coronary intervention (PCI). The aim of this study is to estimate the lifetime attributable risk (LAR) of cancer incidence for individual organs following radiation exposure during PCI in the context of two opposite sides of the angiographic spectrum of coronary occlusive disease: ST-elevation myocardial infarction (STEMI) and chronic coronary total occlusion (CTO). METHODS AND RESULTS: We identified all consecutive patients treated with PCI for STEMI (n ≤ 555) and for CTO (n ≤ 543) in a tertiary care center in 6 years. The LARs of cancer incidence for 6 organs were estimated using the Biological Effects of Ionizing Radiation (BEIR) VII model. The estimated LAR of cancer incidence for individual organs was found to markedly increase as the age of the patient decreased and was significantly higher for the lung (additional risk up to 18/100,000 persons exposed in CTO and 9/100,000 persons exposed in STEMI patients, respectively; P

AB - BACKGROUND: Minimal data exist on the number of additional cancer cases related to radiation exposure following percutaneous coronary intervention (PCI). The aim of this study is to estimate the lifetime attributable risk (LAR) of cancer incidence for individual organs following radiation exposure during PCI in the context of two opposite sides of the angiographic spectrum of coronary occlusive disease: ST-elevation myocardial infarction (STEMI) and chronic coronary total occlusion (CTO). METHODS AND RESULTS: We identified all consecutive patients treated with PCI for STEMI (n ≤ 555) and for CTO (n ≤ 543) in a tertiary care center in 6 years. The LARs of cancer incidence for 6 organs were estimated using the Biological Effects of Ionizing Radiation (BEIR) VII model. The estimated LAR of cancer incidence for individual organs was found to markedly increase as the age of the patient decreased and was significantly higher for the lung (additional risk up to 18/100,000 persons exposed in CTO and 9/100,000 persons exposed in STEMI patients, respectively; P

UR - http://www.scopus.com/inward/record.url?scp=84883595780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883595780&partnerID=8YFLogxK

M3 - Article

C2 - 23995716

AN - SCOPUS:84883595780

VL - 25

SP - 441

EP - 445

JO - Journal of Invasive Cardiology

JF - Journal of Invasive Cardiology

SN - 1042-3931

IS - 9

ER -