Estimating the glomerular filtration rate in the Spanishworking population: Chronic kidney disease prevalence and its associationwith risk factors

Miguel Angel Sánchez-Chaparro, Eva Calvo-Bonacho, Arturo González-Quintela, Martha Cabrera, Luis Quevedo-Aguado, Carlos Fernández-Labandera, Montserrat Ruiz-Moraga, Juan Carlos Sainz-Gutiérrez, Pablo Gómez-Martínez, Javier Román-García, Pedro Valdivielso Felices, Luis Miguel Ruilope, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review


Objective: This study aims to investigate the influence of estimated glomerular filtration rate (eGFR) with two equations (and by one or two separate measurements), on the prevalence of chronic kidney disease (CKD) and its association with blood pressure, and cardiovascular and metabolic risk factors. Methods: Between January 2010 and October 2011, the Ibermutuamur CArdiovascular RIsk Assessment project included 128 588 workers (77.2% men, mean age 39.3 years, range 16-75), who underwent two consecutive yearly medical check-ups and had information for eGFR according to the MDRD-IDMS and CKD-EPI equations (serum creatinine was measured by a isotope-dilution mass spectrometry traceable method in a single central laboratory). CKD was defined by an eGFR less than 60 ml/ min per 1.73m2. Subclinical (occult) renal disease was defined as an eGFR less than 60 ml/min per 1.73m2 in patients with serum creatinine below 1.3 mg/dl and below 1.2 mg/dl in men and women, respectively. Results: In this working population, prevalence of CKD was very low, but two to six times lower when two separate eGFRs below 60 ml/min per 1.73m2 were used. The prevalence of CKD was significantly lower with the CKD-EPI compared to the MDRD-IDMS equation. The same applies to occult CKD. In male workers, occult CKD was practically nonexistent. Multivariate analyses show that blood pressure, total serum cholesterol, and serum glucose (positively), and high-density lipoprotein and low-density lipoprotein (negatively) were associated with CKD, with both equations. Another metabolic factor (waist circumference) was only associated (positively) with CKD defined by the CKD-EPI equation, which appears to be associated with most components of the metabolic syndrome. Conclusions: The CKD-EPI formula, calculated on the basis of two reported blood samples, may provide the most specific definition of CKD.

Original languageEnglish
Pages (from-to)1970-1978
Number of pages9
JournalJournal of Hypertension
Issue number10
Publication statusPublished - Oct 1 2014


  • Cardiovascular risk factors
  • CKD-EPI equations
  • Estimated glomerular filtration rate
  • Working population

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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