### Abstract

The pulmonary O _{2} diffusing capacity (DO _{2}) can be estimated in man from the kinetics of PO _{2} equilibration between lung gas and mixed venous blood during a rebreathing maneuver, when the following variables are known or can be simultaneously determined: mean rebreathing bag volume (VR), mean lung volume (VA), effective ventilation ([rate of change of V]eff), pulmonary capillary blood flow [rate of change of Q], and slope of the blood O _{2} dissociation curve (βO _{2}). Two rebreathing maneuvers, both performed after breathing 11.5% O _{2} in N _{2} at steady state, are required. In the first maneuver, an appropriate volume of 8% CO _{2} in N _{2} is rebreathed for determination of mixed venous blood PO _{2} (P(average V)O _{2}). V)O2. The second maneuver, in which a mixture containing 8% O _{2}, 7% CO _{2}, 20% N _{2}O and 10% He in N _{2} is rebreathed, allows the determination of the remaining variables: the rate constant of PO _{2} equilibration (KO _{2}) from the exponential approach of lung PO _{2} to P(average V)O _{2}; Va and [rate of change of V]eff, from He dilution and mixing rate; [rate of change of Q], from the transfer rate of N _{2}O. The mean DO _{2} value found in 19 experiments on 4 healthy young males at rest was 31 ml/min ^{-1}/Torr ^{-1}. The validity and the applicability of the method are critically discussed.

Original language | English |
---|---|

Pages (from-to) | 526-532 |

Number of pages | 7 |

Journal | Journal of Applied Physiology |

Volume | 37 |

Issue number | 4 |

Publication status | Published - 1974 |

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### ASJC Scopus subject areas

- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation

### Cite this

*Journal of Applied Physiology*,

*37*(4), 526-532.

**Estimation by a rebreathing method of pulmonary O 2 diffusing capacity in man.** / Cerretelli, P.; Veicsteinas, A.; Teichmann, J.; Magnussen, H.; Piiper, J.

Research output: Contribution to journal › Article

*Journal of Applied Physiology*, vol. 37, no. 4, pp. 526-532.

}

TY - JOUR

T1 - Estimation by a rebreathing method of pulmonary O 2 diffusing capacity in man

AU - Cerretelli, P.

AU - Veicsteinas, A.

AU - Teichmann, J.

AU - Magnussen, H.

AU - Piiper, J.

PY - 1974

Y1 - 1974

N2 - The pulmonary O 2 diffusing capacity (DO 2) can be estimated in man from the kinetics of PO 2 equilibration between lung gas and mixed venous blood during a rebreathing maneuver, when the following variables are known or can be simultaneously determined: mean rebreathing bag volume (VR), mean lung volume (VA), effective ventilation ([rate of change of V]eff), pulmonary capillary blood flow [rate of change of Q], and slope of the blood O 2 dissociation curve (βO 2). Two rebreathing maneuvers, both performed after breathing 11.5% O 2 in N 2 at steady state, are required. In the first maneuver, an appropriate volume of 8% CO 2 in N 2 is rebreathed for determination of mixed venous blood PO 2 (P(average V)O 2). V)O2. The second maneuver, in which a mixture containing 8% O 2, 7% CO 2, 20% N 2O and 10% He in N 2 is rebreathed, allows the determination of the remaining variables: the rate constant of PO 2 equilibration (KO 2) from the exponential approach of lung PO 2 to P(average V)O 2; Va and [rate of change of V]eff, from He dilution and mixing rate; [rate of change of Q], from the transfer rate of N 2O. The mean DO 2 value found in 19 experiments on 4 healthy young males at rest was 31 ml/min -1/Torr -1. The validity and the applicability of the method are critically discussed.

AB - The pulmonary O 2 diffusing capacity (DO 2) can be estimated in man from the kinetics of PO 2 equilibration between lung gas and mixed venous blood during a rebreathing maneuver, when the following variables are known or can be simultaneously determined: mean rebreathing bag volume (VR), mean lung volume (VA), effective ventilation ([rate of change of V]eff), pulmonary capillary blood flow [rate of change of Q], and slope of the blood O 2 dissociation curve (βO 2). Two rebreathing maneuvers, both performed after breathing 11.5% O 2 in N 2 at steady state, are required. In the first maneuver, an appropriate volume of 8% CO 2 in N 2 is rebreathed for determination of mixed venous blood PO 2 (P(average V)O 2). V)O2. The second maneuver, in which a mixture containing 8% O 2, 7% CO 2, 20% N 2O and 10% He in N 2 is rebreathed, allows the determination of the remaining variables: the rate constant of PO 2 equilibration (KO 2) from the exponential approach of lung PO 2 to P(average V)O 2; Va and [rate of change of V]eff, from He dilution and mixing rate; [rate of change of Q], from the transfer rate of N 2O. The mean DO 2 value found in 19 experiments on 4 healthy young males at rest was 31 ml/min -1/Torr -1. The validity and the applicability of the method are critically discussed.

UR - http://www.scopus.com/inward/record.url?scp=0016281871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016281871&partnerID=8YFLogxK

M3 - Article

C2 - 4413282

AN - SCOPUS:0016281871

VL - 37

SP - 526

EP - 532

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -