Estimation of coronary flow reserve by sestamibi imaging in patients with mild hypertension and normal coronary arteries

G. Storto, R. Gallicchio, F. Maddalena, T. Pellegrino, M. Petretta, G. Fiumara, A. Cuocolo

Research output: Contribution to journalArticle

Abstract

Aim. Patients with hypertension may exhibit abnormal vasodilator capacity during pharmacological vasodilatation. We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. Methods. Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. CFR was expressed as the ratio of stress to rest MBF. Coronary vascular resistances (CVR) were computed as the ratio between mean arterial pressure and MBF. Results. Estimated MBF at rest was not different in patients and controls (1.11±0.59 vs. 1.14±0.28 counts/pixel/s; P=0.87). Conversely, stress MBF was lower in patients than in controls (1.55±0.47 vs. 2.68±0.53 counts/pixel/s; P

Original languageEnglish
Pages (from-to)336-341
Number of pages6
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume59
Issue number3
Publication statusPublished - Sep 1 2015

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Coronary Vessels
Hypertension
Dipyridamole
Vasodilator Agents
Vasodilation
Vascular Resistance
Pulmonary Artery
Arterial Pressure
Pharmacology

Keywords

  • Fractional flow reserve
  • Hypertension
  • Myocardial
  • Technetium Tc 99m Sestamibi

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Estimation of coronary flow reserve by sestamibi imaging in patients with mild hypertension and normal coronary arteries. / Storto, G.; Gallicchio, R.; Maddalena, F.; Pellegrino, T.; Petretta, M.; Fiumara, G.; Cuocolo, A.

In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 59, No. 3, 01.09.2015, p. 336-341.

Research output: Contribution to journalArticle

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AU - Maddalena, F.

AU - Pellegrino, T.

AU - Petretta, M.

AU - Fiumara, G.

AU - Cuocolo, A.

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