Abstract
Aim. Patients with hypertension may exhibit abnormal vasodilator capacity during pharmacological vasodilatation. We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. Methods. Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. CFR was expressed as the ratio of stress to rest MBF. Coronary vascular resistances (CVR) were computed as the ratio between mean arterial pressure and MBF. Results. Estimated MBF at rest was not different in patients and controls (1.11±0.59 vs. 1.14±0.28 counts/pixel/s; P=0.87). Conversely, stress MBF was lower in patients than in controls (1.55±0.47 vs. 2.68±0.53 counts/pixel/s; P
Original language | English |
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Pages (from-to) | 336-341 |
Number of pages | 6 |
Journal | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
Volume | 59 |
Issue number | 3 |
Publication status | Published - Sep 1 2015 |
Keywords
- Fractional flow reserve
- Hypertension
- Myocardial
- Technetium Tc 99m Sestamibi
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging