Abstract
Aim. Patients with hypertension may exhibit abnormal vasodilator capacity during pharmacological vasodilatation. We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. Methods. Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. CFR was expressed as the ratio of stress to rest MBF. Coronary vascular resistances (CVR) were computed as the ratio between mean arterial pressure and MBF. Results. Estimated MBF at rest was not different in patients and controls (1.11±0.59 vs. 1.14±0.28 counts/pixel/s; P=0.87). Conversely, stress MBF was lower in patients than in controls (1.55±0.47 vs. 2.68±0.53 counts/pixel/s; P
| Original language | English |
|---|---|
| Pages (from-to) | 336-341 |
| Number of pages | 6 |
| Journal | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 59 |
| Issue number | 3 |
| Publication status | Published - Sep 1 2015 |
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Keywords
- Fractional flow reserve
- Hypertension
- Myocardial
- Technetium Tc 99m Sestamibi
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Estimation of coronary flow reserve by sestamibi imaging in patients with mild hypertension and normal coronary arteries. / Storto, G.; Gallicchio, R.; Maddalena, F.; Pellegrino, T.; Petretta, M.; Fiumara, G.; Cuocolo, A.
In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 59, No. 3, 01.09.2015, p. 336-341.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Estimation of coronary flow reserve by sestamibi imaging in patients with mild hypertension and normal coronary arteries
AU - Storto, G.
AU - Gallicchio, R.
AU - Maddalena, F.
AU - Pellegrino, T.
AU - Petretta, M.
AU - Fiumara, G.
AU - Cuocolo, A.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Aim. Patients with hypertension may exhibit abnormal vasodilator capacity during pharmacological vasodilatation. We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. Methods. Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. CFR was expressed as the ratio of stress to rest MBF. Coronary vascular resistances (CVR) were computed as the ratio between mean arterial pressure and MBF. Results. Estimated MBF at rest was not different in patients and controls (1.11±0.59 vs. 1.14±0.28 counts/pixel/s; P=0.87). Conversely, stress MBF was lower in patients than in controls (1.55±0.47 vs. 2.68±0.53 counts/pixel/s; P
AB - Aim. Patients with hypertension may exhibit abnormal vasodilator capacity during pharmacological vasodilatation. We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. Methods. Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. CFR was expressed as the ratio of stress to rest MBF. Coronary vascular resistances (CVR) were computed as the ratio between mean arterial pressure and MBF. Results. Estimated MBF at rest was not different in patients and controls (1.11±0.59 vs. 1.14±0.28 counts/pixel/s; P=0.87). Conversely, stress MBF was lower in patients than in controls (1.55±0.47 vs. 2.68±0.53 counts/pixel/s; P
KW - Fractional flow reserve
KW - Hypertension
KW - Myocardial
KW - Technetium Tc 99m Sestamibi
UR - http://www.scopus.com/inward/record.url?scp=84945184187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945184187&partnerID=8YFLogxK
M3 - Article
C2 - 24658167
AN - SCOPUS:84945184187
VL - 59
SP - 336
EP - 341
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
SN - 1824-4785
IS - 3
ER -