Estimation of non-steady state hepatic glucose production by deconvolution with a time-varying compartmental model

Alfredo Ruggeri, Claudio Cobelli, Andrea Caumo, Geza Hetenyi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hepatic glucose production in dogs was estimated during a nonsteady-state experiment in which the system is perturbed by an insulin infusion and moves from a basal to a hypoglycemic steady state. A tracer is used to probe the system and labeled glucose and unlabeled glucose are measured. The deconvolution technique is applied to the unlabeled glucose data to estimate hepatic glucose production. A previously developed tracer time-varying compartmental model is used to describe the system impulse response.

Original languageEnglish
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages1000-1001
Number of pages2
Editionpt 3
ISBN (Print)0879425598
Publication statusPublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Bioengineering

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