Estimation of the conduction velocity of sympathetic sudomotor C fibres in healthy subjects

Study of sympathetic skin reflex

L. Parisi, P. Rossi, G. Valente, F. Fattapposta, V. Mellina, A. Martini, F. Pierelli, M. Serrao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to establish a simple method for estimating the conduction velocity (CV) of post-ganglionic sympathetic sudomotor C fibres (SSFCV) in the upper and lower limbs by simultaneously measuring the sympathetic skin reflex (SSR) in two distant sites. Fifty healthy volunteers were studied. SSRs were recorded with standard surface electrodes applied to both proximal (axilla and crural line) and distal sites for each limb (hand and foot). The CV of the efferent branch of the SSR was calculated by dividing the difference in the latencies of the response from two recording sites by the distance between the sites (axilla-hand for upper limb; crural line-foot for lower limb). Day-to-day reproducibility and intra-individual variability of the SSFCV were calculated. For the upper limbs, the SSFCV in the axilla-hand tract was 2.0±0.3 m/sec (range 1.6-2.4 m/sec). For the lower limb, the SSFCV in the crural line-foot tract was 1.4 ±0.4 m/sec (range 1.2-1.6 m/sec). Mean intra-individual variability of the SSFCV for the upper and lower limbs was 0.11 and 0.09, respectively. The coefficient of variation of the SSFCV for the upper and lower limbs was 5.1% and 5.4%, respectively. Our data show that this simple and non-invasive method can reliably be used to measure the CV of the sympathetic sudomotor fibres, in suitable temperature conditions, and may be useful when investigating the physiological functions of peripheral nerves in patients with peripheral neuropathies.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalFunctional Neurology
Volume16
Issue number3
Publication statusPublished - 2001

Fingerprint

Unmyelinated Nerve Fibers
Reflex
Lower Extremity
Healthy Volunteers
Axilla
Skin
Foot
Leg
Hand
Upper Extremity
Adrenergic Fibers
Peripheral Nervous System Diseases
Peripheral Nerves
Reaction Time
Electrodes
Extremities
Temperature

Keywords

  • Conduction velocity
  • SSR
  • Sudomotor C fibres

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Parisi, L., Rossi, P., Valente, G., Fattapposta, F., Mellina, V., Martini, A., ... Serrao, M. (2001). Estimation of the conduction velocity of sympathetic sudomotor C fibres in healthy subjects: Study of sympathetic skin reflex. Functional Neurology, 16(3), 231-237.

Estimation of the conduction velocity of sympathetic sudomotor C fibres in healthy subjects : Study of sympathetic skin reflex. / Parisi, L.; Rossi, P.; Valente, G.; Fattapposta, F.; Mellina, V.; Martini, A.; Pierelli, F.; Serrao, M.

In: Functional Neurology, Vol. 16, No. 3, 2001, p. 231-237.

Research output: Contribution to journalArticle

Parisi, L, Rossi, P, Valente, G, Fattapposta, F, Mellina, V, Martini, A, Pierelli, F & Serrao, M 2001, 'Estimation of the conduction velocity of sympathetic sudomotor C fibres in healthy subjects: Study of sympathetic skin reflex', Functional Neurology, vol. 16, no. 3, pp. 231-237.
Parisi, L. ; Rossi, P. ; Valente, G. ; Fattapposta, F. ; Mellina, V. ; Martini, A. ; Pierelli, F. ; Serrao, M. / Estimation of the conduction velocity of sympathetic sudomotor C fibres in healthy subjects : Study of sympathetic skin reflex. In: Functional Neurology. 2001 ; Vol. 16, No. 3. pp. 231-237.
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