Estradiol and progesterone receptors in malignant gastrointestinal tumors

V. Sica, E. Nola, E. Contieri, R. Bova, M. T. Masucci, N. Medici, A. Petrillo, A. Weisz, A. M. Molinari, G. A. Puca

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Abstract

Estradiol and progesterone receptors were assayed in tumors from 79 patients with primary colorectal and 56 patients with stomach adenocarcinomas. Eighteen of 79 colorectal cancers contained estradiol receptor, while 34 specimens were positive for progesterone receptor. In stomach cancer, the positive samples were 8 for estradiol and 14 for progesterone receptors. In both types of tumors, the K(d) was in the range of 10-10 M for estradiol and 10-9 M for progesterone receptor, respectively. In colorectal adenocarcinomas, the presence of progesterone receptor seems to be partially correlated to the presence of estradiol receptor while, in stomach tumors, this correlation is lost. The positivity of at least one receptor in colorectal cancers is higher in the female sex. The contrary occurs for stomach cancer. Sucrose gradient centrifugation showed that cytoplasmic estradiol receptor of stomach cancer sedimented at 8S or 4 to 5S at low ionic strength. The isoelectric point of stomach cancer estradiol receptor is 6.5.

Original languageEnglish
Pages (from-to)4670-4674
Number of pages5
JournalCancer Research
Volume44
Issue number10
Publication statusPublished - 1984

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Estradiol Receptors
Progesterone Receptors
Stomach Neoplasms
Neoplasms
Colorectal Neoplasms
Estradiol
Stomach
Adenocarcinoma
Isoelectric Point
Cytoplasmic and Nuclear Receptors
Centrifugation
Osmolar Concentration
Sucrose

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sica, V., Nola, E., Contieri, E., Bova, R., Masucci, M. T., Medici, N., ... Puca, G. A. (1984). Estradiol and progesterone receptors in malignant gastrointestinal tumors. Cancer Research, 44(10), 4670-4674.

Estradiol and progesterone receptors in malignant gastrointestinal tumors. / Sica, V.; Nola, E.; Contieri, E.; Bova, R.; Masucci, M. T.; Medici, N.; Petrillo, A.; Weisz, A.; Molinari, A. M.; Puca, G. A.

In: Cancer Research, Vol. 44, No. 10, 1984, p. 4670-4674.

Research output: Contribution to journalArticle

Sica, V, Nola, E, Contieri, E, Bova, R, Masucci, MT, Medici, N, Petrillo, A, Weisz, A, Molinari, AM & Puca, GA 1984, 'Estradiol and progesterone receptors in malignant gastrointestinal tumors', Cancer Research, vol. 44, no. 10, pp. 4670-4674.
Sica V, Nola E, Contieri E, Bova R, Masucci MT, Medici N et al. Estradiol and progesterone receptors in malignant gastrointestinal tumors. Cancer Research. 1984;44(10):4670-4674.
Sica, V. ; Nola, E. ; Contieri, E. ; Bova, R. ; Masucci, M. T. ; Medici, N. ; Petrillo, A. ; Weisz, A. ; Molinari, A. M. ; Puca, G. A. / Estradiol and progesterone receptors in malignant gastrointestinal tumors. In: Cancer Research. 1984 ; Vol. 44, No. 10. pp. 4670-4674.
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AU - Petrillo, A.

AU - Weisz, A.

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AU - Puca, G. A.

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