Estradiol and testosterone levels in patients undergoing partial hepatectomy - A possible signal for hepatic regeneration?

A. Francavilla, J. S. Gavaler, L. Makowka, M. Barone, V. Mazzaferro, G. Ambrosino, S. Iwatsuki, F. W. Guglielmi, A. Dileo, A. Balestrazzi, D. H. Van Thiel, T. E. Starzl

Research output: Contribution to journalArticle

Abstract

In five adult male patients undergoing a 40-60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively. Compared to hormone levels found prior to surgery, following major hepatic resection, estradiol levels increase at 24 and 48 hr, while testosterone levels decline, being significantly reduced at 96 and 144 hr. These data demonstrate that adult males who undergo a 40-60% partial hepatectomy experience alterations in their sex hormone levels similar to those observed in male rats following a 70% hepatectomy. These changes in sex hormone levels have been associated in animals with an alteration of the sex hormone receptor status of the liver that is thought to participate in the initiation of the regenerative response. These studies suggest, but do not prove, that in man, as in the case of the rat, sex hormones may participate in the initiation of or at least modulate in part the regenerative response that occurs following a major hepatic resection.

Original languageEnglish
Pages (from-to)818-822
Number of pages5
JournalDigestive Diseases and Sciences
Volume34
Issue number6
DOIs
Publication statusPublished - Jun 1989

Keywords

  • liver regeneration
  • partial hepatectomy
  • steroid hormones

ASJC Scopus subject areas

  • Gastroenterology

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    Francavilla, A., Gavaler, J. S., Makowka, L., Barone, M., Mazzaferro, V., Ambrosino, G., Iwatsuki, S., Guglielmi, F. W., Dileo, A., Balestrazzi, A., Van Thiel, D. H., & Starzl, T. E. (1989). Estradiol and testosterone levels in patients undergoing partial hepatectomy - A possible signal for hepatic regeneration? Digestive Diseases and Sciences, 34(6), 818-822. https://doi.org/10.1007/BF01540264