Estrogen binding by neoplastic human thymus cytosol

F. O. Ranelletti; M. Carmignani; P. Marchetti; C. Natoli; S. Iacobelli

doi:10.1016/0014-2964(80)90334-5

Estrogen binding by neoplastic human thymus cytosol

F. O. Ranelletti, M. Carmignani, P. Marchetti, C. Natoli, S. Iacobelli

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

A binding activity specific for estrogens has been identified in the cytosol of human thymoma. The binder is resolved into 4-5S and 8-9S components by density gradient centrifugation. The analysis of the binding data according to Scatchard revealed the presence of two binding components, one with high affinity and the other with low affinity. The receptor is distinct from the cytoplasmic glucocorticoid receptor on the basis of binding specificity. Specific estrogen binding could be demonstrated in two out of four thymoma cytosols.

Original language	English
Pages (from-to)	951-955
Number of pages	5
Journal	European Journal of Cancer (1965)
Volume	16
Issue number	7
DOIs	https://doi.org/10.1016/0014-2964(80)90334-5
Publication status	Published - 1980

ASJC Scopus subject areas

Oncology

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abstract = "A binding activity specific for estrogens has been identified in the cytosol of human thymoma. The binder is resolved into 4-5S and 8-9S components by density gradient centrifugation. The analysis of the binding data according to Scatchard revealed the presence of two binding components, one with high affinity and the other with low affinity. The receptor is distinct from the cytoplasmic glucocorticoid receptor on the basis of binding specificity. Specific estrogen binding could be demonstrated in two out of four thymoma cytosols.",

author = "Ranelletti, {F. O.} and M. Carmignani and P. Marchetti and C. Natoli and S. Iacobelli",

year = "1980",

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T1 - Estrogen binding by neoplastic human thymus cytosol

AU - Ranelletti, F. O.

AU - Carmignani, M.

AU - Marchetti, P.

AU - Natoli, C.

AU - Iacobelli, S.

PY - 1980

Y1 - 1980

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AB - A binding activity specific for estrogens has been identified in the cytosol of human thymoma. The binder is resolved into 4-5S and 8-9S components by density gradient centrifugation. The analysis of the binding data according to Scatchard revealed the presence of two binding components, one with high affinity and the other with low affinity. The receptor is distinct from the cytoplasmic glucocorticoid receptor on the basis of binding specificity. Specific estrogen binding could be demonstrated in two out of four thymoma cytosols.

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