A binding activity specific for estrogens has been identified in the cytosol of human thymoma. The binder is resolved into 4-5S and 8-9S components by density gradient centrifugation. The analysis of the binding data according to Scatchard revealed the presence of two binding components, one with high affinity and the other with low affinity. The receptor is distinct from the cytoplasmic glucocorticoid receptor on the basis of binding specificity. Specific estrogen binding could be demonstrated in two out of four thymoma cytosols.
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