Estrogen effects of nigral glutamic acid decarboxylase activity: A possible role for catecholestrogen

Ferdinando Nicoletti, Carmela Speciale, Maria Angela Sortino, Maria Stella Panetta, Rosa Maria Di Giorgio, Pier Luigi Canonico

Research output: Contribution to journalArticlepeer-review

Abstract

Repeated but not single injections of estradiol benzoate significantly reduced nigral glutamic acid decarboxylase (GAD, EC 4.1.1.15).). A single injection of the catecholestrogen 2-hydroxyestradiol produced similar results. Tolerance developed to the latter effect, as reflected by the lack of nigral GAD activity changes in rats repeatedly injected with 2-hydroxyestradiol. Repeated injection of the antiestrogen tamoxifen not only failed to antagonize the action of estradiol benzoate but itself reduced nigral GAD activity. Hypophysectomy, which itself decreased nigral GAD activity prevented the lowering effects of either repeated estradiol benzoate administration or single 2-hydroxyestradiol injection on the enzymatic activity.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalEuropean Journal of Pharmacology
Volume115
Issue number2-3
DOIs
Publication statusPublished - Sep 24 1985

Keywords

  • 2-Hydroxyestradiol
  • Estradiol benzoate
  • GAD activity
  • Hypophysectomy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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