Estrogen receptor β expression in human prostate tissue

Daniela Pasquali, Stefania Staibano, Domenico Prezioso, Renato Franco, Dario Esposito, Antonio Notaro, Gaetano De Rosa, Antonio Bellastella, Antonio A. Sinisi

Research output: Contribution to journalArticlepeer-review

Abstract

Estrogen receptor subtype β (ERβ) is highly expressed in rat prostate epithelium, but its presence in human prostate needs to be confirmed. Here we investigated the expression of ERβ in five benign (normal and/or hyperplastic) and 10 malignant (Gleasons' score 2-7) prostate tissue specimens using immunohistochemistry. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, using a commercially available ERβ polyclonal antibody developed against the C-terminal amino acid residue. Nuclear ERβ expression was found in the nuclei of glandular epithelium of benign prostate tissue specimens; faint nuclear ERβ positivity was also present in a few stromal cells around normal epithelium. Nuclear ERβ specific immunostaining was undetectable in all prostate cancer sections.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalMolecular and Cellular Endocrinology
Volume178
Issue number1-2
DOIs
Publication statusPublished - Jun 19 2001

Keywords

  • Estrogen receptor β
  • Estrogen receptors
  • Prostate
  • Prostate cancer

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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