Estrogen receptor β expression in human prostate tissue

Daniela Pasquali; Stefania Staibano; Domenico Prezioso; Renato Franco; Dario Esposito; Antonio Notaro; Gaetano De Rosa; Antonio Bellastella; Antonio A. Sinisi

doi:10.1016/S0303-7207(01)00418-X

Estrogen receptor β expression in human prostate tissue

Daniela Pasquali, Stefania Staibano, Domenico Prezioso, Renato Franco, Dario Esposito, Antonio Notaro, Gaetano De Rosa, Antonio Bellastella, Antonio A. Sinisi

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Estrogen receptor subtype β (ERβ) is highly expressed in rat prostate epithelium, but its presence in human prostate needs to be confirmed. Here we investigated the expression of ERβ in five benign (normal and/or hyperplastic) and 10 malignant (Gleasons' score 2-7) prostate tissue specimens using immunohistochemistry. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, using a commercially available ERβ polyclonal antibody developed against the C-terminal amino acid residue. Nuclear ERβ expression was found in the nuclei of glandular epithelium of benign prostate tissue specimens; faint nuclear ERβ positivity was also present in a few stromal cells around normal epithelium. Nuclear ERβ specific immunostaining was undetectable in all prostate cancer sections.

Original language	English
Pages (from-to)	47-50
Number of pages	4
Journal	Molecular and Cellular Endocrinology
Volume	178
Issue number	1-2
DOIs	https://doi.org/10.1016/S0303-7207(01)00418-X
Publication status	Published - Jun 19 2001

Keywords

Estrogen receptor β
Estrogen receptors
Prostate
Prostate cancer

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

Access to Document

10.1016/S0303-7207(01)00418-X

Fingerprint Dive into the research topics of 'Estrogen receptor β expression in human prostate tissue'. Together they form a unique fingerprint.

Cite this

Estrogen receptor β expression in human prostate tissue. / Pasquali, Daniela; Staibano, Stefania; Prezioso, Domenico; Franco, Renato; Esposito, Dario; Notaro, Antonio; De Rosa, Gaetano; Bellastella, Antonio; Sinisi, Antonio A.

In: Molecular and Cellular Endocrinology, Vol. 178, No. 1-2, 19.06.2001, p. 47-50.

Research output: Contribution to journal › Article › peer-review

@article{9c69ca1d84014024b2d7941b0c1b3483,

title = "Estrogen receptor β expression in human prostate tissue",

abstract = "Estrogen receptor subtype β (ERβ) is highly expressed in rat prostate epithelium, but its presence in human prostate needs to be confirmed. Here we investigated the expression of ERβ in five benign (normal and/or hyperplastic) and 10 malignant (Gleasons' score 2-7) prostate tissue specimens using immunohistochemistry. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, using a commercially available ERβ polyclonal antibody developed against the C-terminal amino acid residue. Nuclear ERβ expression was found in the nuclei of glandular epithelium of benign prostate tissue specimens; faint nuclear ERβ positivity was also present in a few stromal cells around normal epithelium. Nuclear ERβ specific immunostaining was undetectable in all prostate cancer sections.",

keywords = "Estrogen receptor β, Estrogen receptors, Prostate, Prostate cancer",

author = "Daniela Pasquali and Stefania Staibano and Domenico Prezioso and Renato Franco and Dario Esposito and Antonio Notaro and {De Rosa}, Gaetano and Antonio Bellastella and Sinisi, {Antonio A.}",

year = "2001",

month = jun,

day = "19",

doi = "10.1016/S0303-7207(01)00418-X",

language = "English",

volume = "178",

pages = "47--50",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Estrogen receptor β expression in human prostate tissue

AU - Pasquali, Daniela

AU - Staibano, Stefania

AU - Prezioso, Domenico

AU - Franco, Renato

AU - Esposito, Dario

AU - Notaro, Antonio

AU - De Rosa, Gaetano

AU - Bellastella, Antonio

AU - Sinisi, Antonio A.

PY - 2001/6/19

Y1 - 2001/6/19

N2 - Estrogen receptor subtype β (ERβ) is highly expressed in rat prostate epithelium, but its presence in human prostate needs to be confirmed. Here we investigated the expression of ERβ in five benign (normal and/or hyperplastic) and 10 malignant (Gleasons' score 2-7) prostate tissue specimens using immunohistochemistry. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, using a commercially available ERβ polyclonal antibody developed against the C-terminal amino acid residue. Nuclear ERβ expression was found in the nuclei of glandular epithelium of benign prostate tissue specimens; faint nuclear ERβ positivity was also present in a few stromal cells around normal epithelium. Nuclear ERβ specific immunostaining was undetectable in all prostate cancer sections.

AB - Estrogen receptor subtype β (ERβ) is highly expressed in rat prostate epithelium, but its presence in human prostate needs to be confirmed. Here we investigated the expression of ERβ in five benign (normal and/or hyperplastic) and 10 malignant (Gleasons' score 2-7) prostate tissue specimens using immunohistochemistry. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, using a commercially available ERβ polyclonal antibody developed against the C-terminal amino acid residue. Nuclear ERβ expression was found in the nuclei of glandular epithelium of benign prostate tissue specimens; faint nuclear ERβ positivity was also present in a few stromal cells around normal epithelium. Nuclear ERβ specific immunostaining was undetectable in all prostate cancer sections.

KW - Estrogen receptor β

KW - Estrogen receptors

KW - Prostate

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=0035912874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035912874&partnerID=8YFLogxK

U2 - 10.1016/S0303-7207(01)00418-X

DO - 10.1016/S0303-7207(01)00418-X

M3 - Article

C2 - 11403893

AN - SCOPUS:0035912874

VL - 178

SP - 47

EP - 50

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1-2

ER -