Estrogens need insulin-like growth factor i cooperation to exert their neuroprotective effects in post-menopausal women

M. Giunta, A. E. Rigamonti, S. M. Bonomo, M. G. Gagliano, E. E. Müller, E. Scarpini, D. Galimberti, S. G. Cella

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The abrupt fall in estrogens levels during the menopausal transition may connote an hormonal state predisposing to neurodegenerative disorders, e.g. Alzheimer's disease (AD). Reportedly, the neurotrophic activity of estrogen involves an interaction with IGF-I. Aim: To evaluate the leukocyte gene expression of progesterone receptor (PR-A/B) and interleukin 6 (IL-6), two parameters under the control of estrogens and involved in the pathogenesis of AD. Subjects: The study was conducted in non-demented women divided into two groups according to their pre- or post-menopausal state; each group being further divided into two subgroups based on their circulating levels of IGF-I (normal or low). An additional sample of AD-affected women served as a comparison group. Results: Estrogens maintained their full activity only when IGF-I levels were in the range of normalcy. On the contrary, if the concentrations of one or both hormones were reduced, estrogens were not anymore capable to control the gene expression of PR-A/B or IL-6. Conclusions: Before administering hormone-based replacement therapy, characterization of the somatotropic function should be performed in the early phase of the menopause.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalJournal of Endocrinological Investigation
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Alzheimer's disease
  • IGF-I
  • IL-6
  • Menopause
  • Sex hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Estrogens need insulin-like growth factor i cooperation to exert their neuroprotective effects in post-menopausal women'. Together they form a unique fingerprint.

Cite this