Ethanol and dopaminergic systems

L. Lucchi, M. Lupini, S. Govoni, V. Covelli, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the production of cyclic AMP. This finding demonstrates that the dopaminergic receptor associated with adenylate-cyclase activity is affected by chronic ethanol treatment. In particular, the affinity of the dopaminergic receptor labelled by 3H-Spiperone is enhanced. In addition, the receptor-adenylate cyclase coupling system is impaired after chronic in vivo exposure of animals to ethanol.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume18
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1983

Keywords

  • Adenylate cyclase
  • Dopamine receptors
  • Ethanol
  • Guanyl nucleotides
  • Striatal dopaminergic systems

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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