Abstract
Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the production of cyclic AMP. This finding demonstrates that the dopaminergic receptor associated with adenylate-cyclase activity is affected by chronic ethanol treatment. In particular, the affinity of the dopaminergic receptor labelled by 3H-Spiperone is enhanced. In addition, the receptor-adenylate cyclase coupling system is impaired after chronic in vivo exposure of animals to ethanol.
Original language | English |
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Pages (from-to) | 379-382 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 18 |
Issue number | SUPPL. 1 |
DOIs | |
Publication status | Published - 1983 |
Keywords
- Adenylate cyclase
- Dopamine receptors
- Ethanol
- Guanyl nucleotides
- Striatal dopaminergic systems
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology