Ethanol consumption and reward depend on norepinephrine in the prefrontal cortex

Rossella Ventura, Donatina De Carolis, Antonio Alcaro, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

Abstract

We studied the involvement of norepinephrine in the medial prefrontal cortex in the rewarding/reinforcing effects of ethanol. We evaluated the effects of norepinephrine selective depletion in the medial prefrontal cortex of C57/BL6J inbred mice that are commonly used in molecular studies and are highly susceptible to the behavioral effects of ethanol. In mice with prefrontal norepinephrine depletion, ethanol did not induce conditioned place preference, and a clear-cut reduction of ethanol consumption and preference was evident. These results indicate that prefrontal norepinephrine transmission is a critical factor in the rewarding/reinforcing effects of ethanol.

Original languageEnglish
Pages (from-to)1813-1817
Number of pages5
JournalNeuroReport
Volume17
Issue number17
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Alcoholism
  • Norepinephrine
  • Prefrontal cortex
  • Reinforcement
  • Reward

ASJC Scopus subject areas

  • Neuroscience(all)

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