Abstract
The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptors upon nigrostriatal dopaminergic fibers. After chronic ethanol, the same strains develop tolerance to striatal dihydroxyphenylacetic acid increase, while the striatal dopaminergic recognition sites become supersensitive. DBA mice, which have lower numbers of enkephalinergic receptors and higher levels of enkephalins in the striatum, fail to show changes in central dopaminergic function after acute or chronic ethanol treatment. Our results indicate the importance of an interaction between ethanol and opiate receptors in determining the neurochemical and behavioral effects of ethanol.
| Original language | English |
|---|---|
| Pages (from-to) | 260-262 |
| Number of pages | 3 |
| Journal | Psychopharmacology |
| Volume | 74 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1981 |
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Keywords
- Dopamine metabolism
- Ethanol
- Mice
- Opiate receptors
ASJC Scopus subject areas
- Pharmacology
Cite this
Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors. / Barbaccia, Maria Luisa; Reggiani, Angelo; Spano, Pier Franco; Trabucchi, Marco.
In: Psychopharmacology, Vol. 74, No. 3, 07.1981, p. 260-262.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors
AU - Barbaccia, Maria Luisa
AU - Reggiani, Angelo
AU - Spano, Pier Franco
AU - Trabucchi, Marco
PY - 1981/7
Y1 - 1981/7
N2 - The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptors upon nigrostriatal dopaminergic fibers. After chronic ethanol, the same strains develop tolerance to striatal dihydroxyphenylacetic acid increase, while the striatal dopaminergic recognition sites become supersensitive. DBA mice, which have lower numbers of enkephalinergic receptors and higher levels of enkephalins in the striatum, fail to show changes in central dopaminergic function after acute or chronic ethanol treatment. Our results indicate the importance of an interaction between ethanol and opiate receptors in determining the neurochemical and behavioral effects of ethanol.
AB - The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptors upon nigrostriatal dopaminergic fibers. After chronic ethanol, the same strains develop tolerance to striatal dihydroxyphenylacetic acid increase, while the striatal dopaminergic recognition sites become supersensitive. DBA mice, which have lower numbers of enkephalinergic receptors and higher levels of enkephalins in the striatum, fail to show changes in central dopaminergic function after acute or chronic ethanol treatment. Our results indicate the importance of an interaction between ethanol and opiate receptors in determining the neurochemical and behavioral effects of ethanol.
KW - Dopamine metabolism
KW - Ethanol
KW - Mice
KW - Opiate receptors
UR - http://www.scopus.com/inward/record.url?scp=0019470541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019470541&partnerID=8YFLogxK
U2 - 10.1007/BF00427106
DO - 10.1007/BF00427106
M3 - Article
C2 - 6267650
AN - SCOPUS:0019470541
VL - 74
SP - 260
EP - 262
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 3
ER -