Ethnic differences in the degree of morning blood pressure surge and in its determinants between Japanese and european hypertensive subjects: Data from the ARTEMIS study

Satoshi Hoshide, Kazuomi Kario, Alejandro De La Sierra, Grzegorz Bilo, Giuseppe Schillaci, José Ramón Banegas, Manuel Gorostidi, Julian Segura, Carolina Lombardi, Stefano Omboni, Luis Ruilope, Giuseppe Mancia, Gianfranco Parati

Research output: Contribution to journalArticlepeer-review

Abstract

Morning blood pressure (BP) surge has been reported to be a prognostic factor for cardiovascular events. Its determinants are still poorly defined, however. In particular, it is not clear whether ethnic differences play a role in determining morning surge (MS) size. Aim of our study was to explore whether differences exist in the size of MS between Japanese and Western European hypertensive patients. We included 2887 untreated hypertensive patients (age 62.3±8.8 years) from a European ambulatory BP monitoring database and 811 hypertensive patients from a Japanese database (Jichi Medical School Ambulatory Blood Pressure Monitoring WAVE1, age 72.3±9.8 years) following the same inclusion criteria. Their 24-hour ambulatory BP monitoring recordings were analyzed focusing on MS. Sleep-trough MS was defined as the difference between mean systolic BP during the 2 hours after awakening and mean systolic BP during the 1-hour night period that included the lowest sleep BP level. The sleep-trough MS was higher in Japanese than in European hypertensive patients after adjusting for age and 24-hour mean BP levels (40.1 [95% confidence interval 39.0-41.2] versus 23.0 [22.4-23.5] mm Hg; P

Original languageEnglish
Pages (from-to)750-756
Number of pages7
JournalHypertension
Volume66
Issue number4
DOIs
Publication statusPublished - Oct 11 2015

Keywords

  • ambulatory blood pressure monitoring
  • arterial hypertension
  • blood pressure variability
  • cardiovascular events
  • ethnicity
  • morning blood pressure surge
  • sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

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